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#5
Environ 80 % du modafinil est mГ©tabolisГ© par le foie et il est principalement Г©liminГ© sous forme inchangГ©e dans les urines. Il a Г©tГ© dГ©couvert par la sociГ©tГ© pharmaceutique Medivir. Bien que le mГ©canisme exact de cette action ne soit pas entiГЁrement compris, la recherche sur la maladie de Parkinson a montrГ© que le modafinil augmente l'Г©veil et diminue la somnolence. La dose recommandГ©e est de 100 mg une fois par jour Г  prendre approximativement au coucher. Le modafinil est une poudre cristalline blanche Г  lГ©gГЁrement jaunГўtre avec un point de fusion de 152,8-153,5В°C. Il a Г©tГ© dГ©montrГ© que le modafinil augmente la monoamine oxydase A (MAOA), une enzyme impliquГ©e dans le mГ©tabolisme de la dopamine. Cela augmente l'Г©veil et amГ©liore la mГ©moire chez les personnes atteintes de narcolepsie. Modafinil a Г©tГ© trouvГ© pour stimuler la synthГЁse de Dopamine. La mГЄme chose a Г©tГ© notГ©e dans les Г©tudes avec des enfants. Le risque de dГ©pendance est faible et peut ГЄtre liГ© au mode de consommation. modiodal drogue En outre, il peut Г©galement ГЄtre impliquГ© dans la libГ©ration d'acГ©tylcholine dans le prosencГ©phale basal. Ses propriГ©tГ©s "favorisant l'Г©veil" ne sont pas altГ©rГ©es par des doses rГ©guliГЁres d'alcool. Il est gГ©nГ©ralement pris sous forme de pilule trois fois par jour, ou sous forme de comprimГ© sublingual trois fois par jour, Г  une dose de 25 Г  100 mg par jour, bien que des doses aussi Г©levГ©es que 200 mg par jour aient Г©tГ© utilisГ©es. Modafinil augmente le lecteur vers Г©veillГ© par la libГ©ration de ces neurotransmetteurs. Il peut Г©galement provoquer une gГЄne abdominale et une Г©ruption cutanГ©e ou des dГ©mangeaisons, qui peuvent ressembler Г  une dermatite de contact. Il diffГЁre des stimulants qui maintiennent naturellement une personne Г©veillГ©e (comme la cafГ©ine et la nicotine), car il ne crГ©e pas d'accoutumance. On pense que le modafinil agit en imitant certains neurotransmetteurs. Le modafinil est disponible en tant que mГ©dicament gГ©nГ©rique. Les femmes enceintes ou qui envisagent de devenir enceintes ne doivent pas les prendre. Il est recommandГ© de prendre les doses Г  au moins 4 heures d'intervalle afin d'Г©viter les effets secondaires potentiellement somnifГЁres. Il le fait en se liant et en activant le rГ©cepteur de l'adГ©nosine A2A.

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Le modafinil se prend avec de la nourriture et doit être pris avec du lait écrémé ou des substituts du lait. Ceci n'est pas cohérent avec l'action unique de l'amphétamine (qui augmente la dopamine, la noradrénaline et la sérotonine et n'inhibe pas le système noradrénergique) mais est cohérent avec d'autres stimulants centraux. Le composant principal est la forme R, représentant environ 75 % du total, tandis que l'isomère S représente environ 5 %. Disponible en tant que médicament générique, le modafinil est vendu aux États-Unis sous le nom de Provigil depuis 2001. Le modafinil ne doit pas être pris avec de la nourriture, des boissons ou d'autres médicaments susceptibles de provoquer de la somnolence, sauf avis contraire d'un médecin. Une fois l'éveil établi, le médicament semble avoir un effet soutenu qui cible les systèmes responsables du maintien de la vigilance. Il est disponible en doses de 100 mg, 200 mg et 400 mg. Les échantillons de modafinil sont jaunes à brun-orangé, et généralement sous la forme d'une fine poudre. Le médicament a réussi à plus de 90% à modifier les habitudes de sommeil des patients atteints de narcolepsie et était, à l'époque, l'un des premiers médicaments à avoir réussi à traiter ce trouble. Le modafinil agit pour augmenter la quantité de dopamine dans le cerveau, améliorant potentiellement la sensation de bien-être. C'est aussi une option de traitement pour les catapres. L'effet secondaire le plus courant est une somnolence modérée. modiodal drogue La narcolepsie provoque des symptômes tels qu'une somnolence soudaine et intense, des hallucinations et une paralysie du sommeil. La liaison protéique du modafinil a été évaluée entre 0,95 et 0,98. Il n'est pas clair si les effets stimulants du modafinil sont une fonction de ses activités pharmacologiques, ou sont une conséquence d'une activité pharmacologique distincte. Le modafinil a également été approuvé par la FDA pour le traitement des troubles du sommeil liés au travail posté, y compris dans le traitement de la somnolence excessive chez les patients narcoleptiques. On pense que le modafinil agit en augmentant les niveaux de dopamine dans le cerveau et en aidant au fonctionnement de certaines régions cérébrales impliquées dans l'éveil, telles que le cortex et les lobes frontaux. HHS Act : avant son approbation pour un usage médical, les États-UnisLa Food and Drug Administration (FDA) a approuvé l'utilisation du modafinil dans le traitement de la somnolence diurne excessive associée à la narcolepsie, aux troubles du sommeil liés au travail posté et à l'apnée obstructive du sommeil. Le modafinil, vendu entre autres sous le nom de marque Provigil, est un stimulant du système nerveux central (SNC) utilisé pour traiter la somnolence due à la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Le modafinil est également utilisé pour le traitement de certains types de dépression et comme aide à la perte de poids. La posologie quotidienne varie de 400 mg à 600 mg. Le médicament est produit par la division Pfizer de Johnson & Johnson. Les comprimés enrobés de modafinil sont les plus efficaces, avec une biodisponibilité accrue à partir d'un pelliculage en raison d'un environnement à pH acide et d'une libération accrue du médicament. Il est métabolisé en quatre produits inactifs. D'autres facteurs peuvent également influencer la façon dont le modafinil interagit avec vos autres médicaments, vous devez donc en parler à votre médecin.

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#6
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#7
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#8
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#9
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