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06-21-2023, 09:41 PM
(This post was last modified: 06-21-2023, 09:42 PM by Le Modafinil.)
Si une personne atteinte de narcolepsie ne faisait pas de sieste pendant la journГ©e, elle serait Г©puisГ©e pendant la journГ©e. Un mГ©tabolite actif du modafinil, le desmГ©thyl-modafinil, Г©tait Г©galement efficace pour amГ©liorer l'Г©veil, en particulier chez les personnes atteintes de narcolepsie. Ce n'est pas la mГЄme chose que les agonistes de la dopamine, qui peuvent entraГ®ner une tolГ©rance et une dГ©pendance. C'est un mГ©lange racГ©mique de deux formes Г©nantiomГЁres ; l'isomГЁre D le plus actif est le R-modafinil. La dose typique de modafinil est de 100 Г 200 mg par jour. Cette action oblige votre cerveau Г rester alerte. Le modafinil est disponible en cinq dosages, 100 mg, 200 mg, 300 mg, 400 mg et 500 mg. Il ne doit pas ГЄtre administrГ© aux patients utilisant des inducteurs du CYP3A4 (par exemple la rifampicine) ou des inhibiteurs du CYP2D6 ou du CYP2C19, Г moins que le patient ne soit Г©troitement surveillГ© pour la survenue d'effets indГ©sirables. Les principaux effets de la prise de Modafinil comprennent la vigilance, la stimulation mentale et l'amГ©lioration de l'attention. La dose quotidienne totale de modafinil oral est de 100 Г 200 mg, prise juste avant le coucher. Le principal mГ©tabolite actif du modafinil est le N-desmГ©thylmodafinil. systГЁme nerveux central. Cela conduit Г une sensation d'Г©veil, Г une somnolence rГ©duite et Г moins de fatigue. modafinil france acheter Il existe diffГ©rentes qualitГ©s disponibles, en fonction de la quantitГ© de mГ©dicament. De tels risques sont extrГЄmement rares mais peuvent survenir. Bien que la narcolepsie avec cataplexie soit une maladie gГ©nГ©tique, les chercheurs ont observГ© que la narcolepsie s'accompagne souvent d'une privation de sommeil en raison du travail de nuit, et le modafinil semble rendre les personnes atteintes des deux troubles du sommeil plus alertes qu'elles ne le seraient autrement. Le modafinil est utilisГ© pour traiter des affections telles que les troubles du sommeil liГ©s au travail postГ©, la narcolepsie, l'apnГ©e obstructive du sommeil et autres. Effets secondaires du modafinil Les personnes atteintes de certains troubles psychiatriques, y compris le trouble bipolaire, doivent Г©viter de prendre du Modafinil car il peut provoquer une manie. Des rГ©actions plus graves telles que des allergies, des symptГґmes psychotiques ou des effets secondaires similaires peuvent survenir chez certaines personnes. Le modafinil est un mГ©tabolite actif du mГ©dicament Provigil, lancГ© en 1998 et commercialisГ© en France depuis 1994. Comme le mГ©thylphГ©nidate, il agit en se liant au transporteur de la dopamine dans le cerveau. Les personnes qui doivent rester Г©veillГ©es pour travailler tout le temps, surtout la nuit, sont les personnes les plus courantes qui utilisent le modafinil. Les symptГґmes peuvent inclure une paralysie du sommeil, des rГЄves vifs, une sensibilitГ© accrue Г la lumiГЁre et au son et une somnolence diurne. Le modafinil a Г©tГ© dГ©veloppГ© Г l'origine pour ГЄtre utilisГ© dans la recherche sur le sommeil et a Г©tГ© utilisГ© pour traiter la narcolepsie et d'autres troubles du sommeil pendant des dГ©cennies avant d'entrer sur le marchГ© en tant que mГ©dicament d'ordonnance en 1997. Les doses sont de 100 milligrammes immГ©diatement avant d'aller au lit, 100 milligrammes juste avant la premiГЁre pГ©riode de rГ©veil actif et les 100 milligrammes finaux le matin. Pour l'insomnie chez l'adulte, des doses de modafinil de 100 Г 400 mg sont couramment utilisГ©es В« au besoin В». Il est rapidement absorbГ© aprГЁs administration orale et sa concentration plasmatique maximale est atteinte aprГЁs 1 Г 2 heures. Le modafinil est une phГ©nГ©thylamine.
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On pense qu'il agit en activant les rГ©cepteurs postsynaptiques dans le SNC pour ces neurotransmetteurs. Il a Г©tГ© proposГ© que cela se traduit par un rГ©veil, une vigilance et une attention amГ©liorГ©e. C'est un agent "favorisant l'Г©veil". Les personnes ayant des antГ©cГ©dents de convulsions devraient Г©viter de le prendre. Le sommeil est essentiel au bien-ГЄtre physique, mental et Г©motionnel. Le modafinil ne semble pas interagir avec l'alcool ni affecter la rГ©ponse habituelle de l'organisme Г l'alcool. Il est utilisГ© pour traiter la somnolence rГ©sultant de la narcolepsie et des troubles du travail postГ©, et peut ГЄtre utilisГ© en complГ©ment du traitement de l'apnГ©e obstructive du sommeil pour permettre aux personnes de dormir pendant la nuit sans arrГЄter de respirer. Le modafinil est couramment utilisГ© pour traiter la somnolence excessive causГ©e par la narcolepsie et le syndrome du travail postГ©. Par consГ©quent, il aide Г stimuler les neurones et les cellules nerveuses du cerveau. Il augmente la transmission de son signal en bloquant une enzyme qui dГ©truit la dopamine. On ne sait pas comment les effets fonctionnent chez l'homme. Au Canada, il est classГ© comme substance contrГґlГ©e de l'annexe IV. modafinil france acheter La qualitГ© du sommeil autodГ©clarГ©e s'est amГ©liorГ©e significativement plus chez les patients prenant du modafinil que dans le groupe placebo. L'arrГЄt est recommandГ© dГЁs les premiers signes d'Г©ruption cutanГ©e ou de rГ©actions similaires. Modafinil est une poudre cristalline blanche Г blanc cassГ© qui peut ГЄtre prise par voie orale. Le mГ©canisme d'action exact du modafinil n'est pas clair. Il agit en augmentant les niveaux de dopamine dans le cerveau, ce qui affecte l'Г©veil. L'hydroxy-modafinil est le principal mГ©tabolite trouvГ© dans l'urine, tandis que la phГ©nacГ©tine conjuguГ©e et sa forme Г©nol inactive sont excrГ©tГ©es dans l'urine. En consГ©quence, il semble ГЄtre trГЁs efficace dans sa capacitГ© Г amГ©liorer l'attention et la vigilance, ainsi qu'Г amГ©liorer la mГ©moire et la motivation. Il n'y a pas d'Г©tudes validГ©es examinant si le modafinil amГ©liore la cognition. L'amГ©lioration de ce mГ©canisme peut ГЄtre la raison de l'utilisation rГ©ussie du modafinil dans le travail postГ©. Le modafinil est le seul mГ©dicament non stimulant censГ© activer ces voies dans le cerveau. Des suppositoires de modafinil sont Г©galement disponibles.
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