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06-22-2023, 03:16 AM
(This post was last modified: 06-22-2023, 03:17 AM by Le Modafinil.)
Le modafinil est un mГ©dicament d'ordonnance. Le modafinil est disponible sous le nom d'Armodafinil en Europe, H 22525 aux Г‰tats-Unis et au Canada, Modastim au Royaume-Uni et Provigil dans le reste du monde. Certaines rumeurs suggГЁrent que le mГ©dicament permet aux travailleurs privГ©s de sommeil de fonctionner de maniГЁre plus productive lorsqu'ils ne sont pas au bureau, bien que ce soit faux. L'arrГЄt est recommandГ© dГЁs les premiers signes d'Г©ruption cutanГ©e ou de rГ©actions similaires. Le modafinil, lorsqu'il est utilisГ© comme activateur cognitif, peut amГ©liorer certaines fonctions du SNC, notamment l'attention, la vigilance et la concentration. Le modafinil est un produit chimique proche du mГ©thylphГ©nidate de modafinil. Une action plus directe sur le cerveau est probablement responsable de l'effet documentГ© dans le traitement de la narcolepsie, ainsi que d'autres symptГґmes de la maladie. MГ©canisme d'action : Un analogue de la dopamine non stimulant qui agit sur le systГЁme noradrГ©nergique du SNC. Le modafinil est disponible en comprimГ©s de 50 mg, 100 mg et 150 mg. Dans ces cas, il a eu des rГ©sultats mitigГ©s. Le modafinil est fabriquГ© aux Г‰tats-Unis par Novartis sous forme de comprimГ© Г des doses de 100 Г 200 mg. Г‰tant donnГ© que le mГ©dicament est un mГ©lange racГ©mique de deux isomГЁres optiques, chaque isomГЁre a un effet pharmacologique diffГ©rent. Le modafinil se prend par voie orale. modafinil Ne les utilisez pas ensemble. Alors que ses recherches initiales et ses essais cliniques ont Г©tГ© financГ©s par GlaxoSmithKline (maintenant Glaxo Wellcome), le mГ©dicament a Г©tГ© pris en dГ©veloppement privГ© par Lafon Laboratories, et a ensuite Г©tГ© commercialisГ© par Intervet International. Le modafinil est un analogue de la phГ©nГ©thylamine et est un stimulant du SNC. Le modafinil peut ГЄtre utilisГ© comme thГ©rapie de remplacement de la narcolepsie, mais il n'est pas largement utilisГ©, car il a peu d'effet s'il est utilisГ© seul. Le modafinil semble agir principalement sur les zones du cerveau impliquГ©es dans l'Г©veil et l'activitГ© motrice. On pense Г©galement que le modafinil est efficace dans le traitement du TDAH, des troubles du sommeil dus au dГ©calage horaire ou Г la fatigue du voyage, et de la fatigue associГ©e Г la sclГ©rose en plaques. Le modafinil est absorbГ© relativement rapidement aprГЁs administration orale, avec une concentration plasmatique maximale observГ©e en 6 Г 9 heures. Le modafinil 600 mg n'est pas commercialisГ© aux Г‰tats-Unis. Modafinil contient les ingrГ©dients actifs suivants : Physiquement, le Modafinil est une poudre cristalline blanche Г blanc cassГ© avec un point de fusion de 122-123В°C. Le sildГ©nafil, le vardГ©nafil et le tadalafil sont tous des mГ©dicaments oraux de la mГЄme famille chimique que le modafinil et ont tous des mГ©canismes d'action similaires. Il possГЁde un mГ©canisme d'action unique dГ©couvert Г l'origine par Michel Jouvet et les Laboratoires Lafon. La dose recommandГ©e est de 100 mg une fois par jour Г prendre approximativement au coucher. Le modafinil est disponible en doses de 150 mg, 200 mg et 400 mg. Le modafinil est un agent induisant une libГ©ration indirecte de dopamine. Le modafinil peut ГЄtre pris le matin avec ou sans nourriture.
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Le médicament semble améliorer l'attention et la mémoire de travail dans les tâches cognitives en augmentant les niveaux de dopamine, à la fois au centre du cerveau et en périphérie dans la circulation sanguine. Un nouveau comprimé pelliculé a été approuvé par la FDA en 2016. Assurez-vous de demander conseil à votre médecin avant de l'utiliser. C'est un médicament à forte dose () avec une demi-vie d'environ 50 heures. chez les patients ayant des antécédents de telles conditions). Modafinil est disponible dans plusieurs pays du monde. En 2015, des études d'imagerie cérébrale menées par une équipe de l'UCLA, de l'Université de Liverpool et de l'Université de Columbia à New York ont ​​montré que le modafinil pouvait améliorer la motivation et l'attention, en augmentant les régions cérébrales impliquées dans la motivation et en réduisant les régions liées à la dépendance. Il n'interagit pas avec les inhibiteurs ou inducteurs d'ETOX dérivés du cytochrome P-450. On dit aussi qu'il améliore la clarté de la pensée et la concentration. Le ligand naturel est le GABA, mais pour avoir l'effet du modafinil (ou d'autres médicaments stimulants) sur le SNC, ces agents doivent se lier à des sites spéciaux sur les récepteurs GABA. La durée de traitement recommandée est généralement de quatre à huit semaines. Le modafinil et l'armodafinil, un médicament similaire, sont appelés agents «favorisant l'éveil», car ils peuvent être capables de stimuler l'éveil. Il est également disponible en gélules de 100 mg et en 25 ou 50 mg. La recherche sur le modafinil est en cours, mais les résultats à ce jour sont mitigés. modafinil De cette manière, il peut également avoir un effet sur la libération d'acide gamma-aminobutyrique (GABA). Le modafinil est un mélange racémique de deux isomères optiques, ou énantiomères, le R-(+)-modafinil et le S-(-)-modafinil. Les comprimés de 300 mg et 100 mg peuvent être avalés entiers. La dose efficace la plus faible correspond au quart de la dose quotidienne prise pendant une période plus longue. Le modafinil est un agoniste de la dopamine plus constant et a une plus grande efficacité dans les études animales que le méthylphénidate. Les effets secondaires comprennent des maux de tête, des troubles du sommeil et des nausées. Ceux-ci peuvent être plus fréquents chez les patients pédiatriques, qui ont besoin de doses plus faibles. Le modafinil a une courte demi-vie plasmatique de 30 à 90 minutes et est métabolisé par la bêta-oxydation des acides gras. Des suppositoires de modafinil sont également disponibles. Il augmente les concentrations extracellulaires de dopamine dans les ganglions de la base. Le réveil brutal dû à un trouble du sommeil sous-jacent entraîne un cycle de sommeil chaotique. Le modafinil est légèrement plus puissant que l'amphétamine et est environ trois fois plus puissant que le méthylphénidate moins connu.
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