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#7
Les rapports d'éveil, de vigilance et de concentration accrus suggèrent qu'il pourrait être bénéfique chez les personnes présentant des déficits cognitifs associés à des troubles tels que les troubles cognitifs légers, la maladie d'Alzheimer, le syndrome de Down ou le trouble déficitaire de l'attention avec hyperactivité (TDAH). Le modafinil est un inhibiteur de la recapture de la noradrénaline-dopamine qui augmente la disponibilité de la noradrénaline et de la dopamine dans le cerveau des patients. L'effet secondaire le plus courant est la difficulté à dormir. La dépendance au modafinil est possible. Ceux-ci comprenaient des nausées (2 %), de la diarrhée (1 %), des vomissements (0,5 %), des douleurs à l'estomac (0,1 %) ou des brûlures d'estomac (0,1 %). Le modafinil peut également être utilisé pour traiter les personnes souffrant d'apnée obstructive du sommeil, qui est un trouble du sommeil qui rend la respiration plus difficile pour une personne. Cela se produit environ 8 heures après les premiers effets du modafinil, il ne s'agit donc pas d'un effet immédiat. Le modafinil est une substance active dérivée des amphétamines, en particulier du médicament lisdexamfétamine, qui est une amphétamine faible qui se lie aux récepteurs de la sérotonine du cerveau. Il agit en augmentant les neurotransmetteurs noradrénaline et dopamine dans le système nerveux central. Il est également utilisé pour traiter le SWSD, un trouble du sommeil qui provoque une somnolence diurne excessive dans laquelle la personne se réveille fatiguée et ne se rendort pas après le réveil. Le modafinil diffère des autres stimulants, tels que les amphétamines, qui activent le système dopaminergique et augmentent l'éveil. Le modafinil, comme la caféine et la dextroamphétamine, est un dérivé méthylé de l'amphétamine. Le modafinil est un médicament générique disponible sous forme de comprimé, de comprimé, de comprimé, de comprimé ou de médicament liquide. Les mécanismes précis par lesquels le modafinil affecte le SNC ne sont pas encore compris. En 2012, les régulateurs français ont approuvé le médicament pour le traitement de la somnolence excessive chez les patients souffrant de troubles du sommeil liés au travail posté, et en 2016, ils l'ont approuvé pour le traitement de la somnolence excessive due à l'apnée du sommeil. modafinil belgique Le modafinil a été découvert pour stimuler la production de dopamine et de sérotonine chez la souris. Pour l'administration orale, le médicament est pris 15 à 30 minutes avant le coucher. Le modafinil agit principalement en améliorant la disponibilité du neurotransmetteur dopamine dans le cerveau. Les effets indésirables sont généralement légers et la dose normale de modafinil est de 100 à 400 mg par jour (deux fois par jour) ou de 200 à 800 mg (une fois par jour). Il peut être purifié par des techniques telles que la cristallisation et le broyage. MOD peut atténuer la somnolence chez les personnes fatiguées, en particulier chez les travailleurs postés, leur permettant de rester éveillés et alertes plus longtemps. Des tests plus récents de nouvelles utilisations sont également à venir. Utilisé seul ou en association avec un placebo, les doses ont varié de 50 à 200 mg, administrées 2 à 6 fois par jour. Le GABA est un neurotransmetteur inhibiteur clé, agissant dans le cerveau pour permettre l'inhibition. Le modafinil peut être un traitement efficace pour plusieurs conditions, y compris la narcolepsie. Les stimulants peuvent stimuler plusieurs parties du système dopaminergique, y compris le cortex préfrontal et le système mésolimbique. Le modafinil ne semble pas avoir d'interactions cliniquement significatives avec d'autres médicaments. Cela peut prendre une à cinq semaines pour développer tous les effets. Avec la nourriture, l'effet secondaire le plus courant est le mal de tête.

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Le modafinil est approuvГ© pour le traitement de la somnolence excessive associГ©e Г  la narcolepsie chez les adultes, ainsi que pour les troubles du sommeil liГ©s au travail postГ© chez les adultes. Modafinil augmente le lecteur vers Г©veillГ© par la libГ©ration de ces neurotransmetteurs. Il existe de nombreuses variantes de marque de Modafinil, notamment Afinil, Arium, Campral, Centrobid, Concerta, Cogentin, Desmodin, Modana, Modvigil, Novaday, Nuvigil, Nuvigil Infusion, Provigil, Respifine, Ritalin, Ritalin LA, Ritalin XL et Rythmodan. C'est un stimulant sГ©lectif Г  action centrale du SNC. Le modafinil a une demi-vie d'Г©limination de 6 Г  8 heures chez les individus en bonne santГ©. La substance est commercialisГ©e comme mГ©dicament dans un certain nombre de pays, dont les Г‰tats-Unis, le Royaume-Uni, le Japon, IsraГ«l, la ThaГЇlande, le Canada, la Finlande, la France, l'Allemagne, l'Espagne, l'Italie et bien d'autres. Le modafinil est un stimulant sГ©lectif non amphГ©tamine. Ce n'est pas un sympathomimГ©tique Г  action directe. L'industrie pharmaceutique identifie le modafinil comme C15H12N2O, dont la formule chimique est indiquГ©e ci-dessus. La mesure du mГ©tabolite actif pourrait ГЄtre un meilleur indicateur de sa pharmacocinГ©tique que la mesure de la concentration de modafinil lui-mГЄme. Le modafinil a Г©galement un effet central possible sur l'acide gamma-aminobutyrique (GABA), similaire Г  l'effet d'autres benzodiazГ©pines. L'effet sur la libГ©ration de dopamine et de noradrГ©naline module la libГ©ration d'autres neurotransmetteurs, qui peuvent Г©galement contribuer aux effets du Modafinil. modafinil belgique Il existe une variation substantielle du taux d'absorption entre les individus, qui est liГ©e Г  l'activitГ© de l'enzyme CYP1A2 du cytochrome P450. L'efficacitГ© du modafinil est due Г  sa capacitГ© Г  augmenter les niveaux de dopamine dans le striatum en bloquant les transporteurs de recapture qui Г©liminent la dopamine de la fente synaptique. L'approbation du Modafinil pour le traitement de la somnolence diurne excessive est basГ©e sur un examen des directives de 2001 de l'American Academy of Sleep Medicine pour la narcolepsie. Comme la plupart des stimulants, il agit dans le systГЁme noradrГ©naline (NE), le systГЁme responsable du rГ©veil du corps, des tГўches normales et de la vie quotidienne. Le modafinil, comme la plupart des stimulants, peut provoquer une migraine, des troubles du sommeil et Г©ventuellement une irritabilitГ©. Depuis son dГ©veloppement initial, le modafinil a fait l'objet de recherches pour son utilisation comme mГ©dicament contre la somnolence excessive associГ©e au travail postГ© ou Г  la narcolepsie, mais il a des utilisations hors AMM pour le traitement du В«dГ©calage horaireВ», de la В«diminution de la performance au travail liГ©e Г  la somnolenceВ» et autres syndromes de somnolence diurne excessive. Le modafinil est gГ©nГ©ralement bien tolГ©rГ©. De plus, Modafinil elimite est disponible. La rГ©gion du cerveau qui contrГґle la vigilance s'appelle le locus coeruleus et contrГґle le sommeil et l'Г©veil. Il peut ГЄtre pris n'importe oГ№ jusqu'Г  trois fois par jour, mais il doit ГЄtre espacГ© d'au moins 3 heures. Il est recommandГ© que les personnes atteintes de maladie cardiaque soient Г©troitement surveillГ©es pendant la prise d'un mГ©dicament de ce type. Ces mГ©dicaments peuvent vous aider Г  rester Г©veillГ© lorsque vous vous sentez fatiguГ© ou somnolent. Le modafinil augmente les niveaux extracellulaires de dopamine dans le cortex prГ©frontal dorsolatГ©ral, une rГ©gion responsable de l'attention, de la vitesse de traitement et de la mГ©moire de travail. Les rГ©cepteurs D2 sont exprimГ©s dans les zones du cerveau impliquГ©es dans le rythme circadien qui rГ©gulent le sommeil, l'Г©veil et d'autres aspects du cycle du sommeil, tels que le systГЁme limbique et l'hypothalamus, en particulier le noyau accumbens. Modafinil est pris une fois par jour.

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#8
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#9
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#10
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