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(This post was last modified: 06-22-2023, 08:45 PM by Le Modafinil .)
Le modafinil est bien absorbГ© aprГЁs administration orale, avec des concentrations sanguines maximales survenant 1 Г 3 heures aprГЁs l'ingestion. Il a Г©tГ© suggГ©rГ© que l'effet est dГ» aux effets stimulants du Modafinil agissant sur le systГЁme nerveux central. Le modafinil a Г©tГ© testГ© comme alternative aux stimulants tels que l'amphГ©tamine et constitue un traitement efficace et bien tolГ©rГ© pour les troubles du sommeil et les troubles du sommeil liГ©s au travail postГ©. Le modafinil est disponible en doses de 150 mg, 200 mg et 400 mg. Il est recommandГ© d'Г©viter de prendre du modafinil pendant le traitement avec l'un de ces mГ©dicaments. Il a Г©tГ© approuvГ© pour une utilisation hors indication pour le traitement de la somnolence associГ©e au trouble du sommeil liГ© au travail postГ© (SWED) aux Г‰tats-Unis en 2004. Le modafinil est disponible sous forme de comprimГ©s oraux de modafinil Г 100 mg. En tant que deuxiГЁme gГ©nГ©ration de mГ©dicaments nootropiques, le modafinil appartient au groupe chimique des dГ©rivГ©s de l'amphГ©tamine. Cependant, ces effets ne sont pas garantis et peuvent s'accompagner d'effets secondaires dГ©sagrГ©ables. La rГ©gion du cerveau qui contrГґle la vigilance s'appelle le locus coeruleus et contrГґle le sommeil et l'Г©veil. Le syndrome de Stevens-Johnson ou nГ©crolyse Г©pidermique toxique, y compris l'anaphylaxie, a Г©galement Г©tГ© signalГ© Г un taux de 0,1 Г 0,2 pour 10 000 utilisateurs. Lorsque la dopamine est stimulГ©e de cette maniГЁre, elle provoque la libГ©ration de noradrГ©naline qui augmente la vigilance et l'Г©veil. En Suisse, le modafinil est disponible sous forme de comprimГ©, de comprimГ© Г libГ©ration prolongГ©e et de liquide. La forme posologique SR se prend une fois par jour le matin. Selon l'OMS, Modafinil est le nom chimique de la 2-(diphГ©nylmГ©thyl)-1-p-benzoylpyrrolidine, et est une phГ©nГ©thylamine Г activitГ© stimulante.
modafinil canada Il peut ГЄtre prescrit par un mГ©decin aux Г‰tats-Unis. Le modafinil peut ГЄtre le meilleur choix pour rГ©duire la somnolence chez les personnes atteintes de narcolepsie. Un essai contrГґlГ© randomisГ© chez des travailleurs postГ©s souffrant de somnolence a montrГ© une augmentation de la vigilance et de l'Г©veil de 20 % aprГЁs huit semaines de traitement avec 100 mg de modafinil. Des cas de psychose ont Г©tГ© signalГ©s chez des personnes prenant du modafinil, notamment des hallucinations et des dГ©lires. En Europe, il est vendu sous le nom de Provigil au Royaume-Uni, sous le nom de Modavigil en Allemagne et sous le nom de Modesic en Italie et en Irlande. Le modafinil ne doit pas ГЄtre pris avec de l'alcool, d'autres dГ©presseurs du SNC ou des inducteurs puissants ou potentiellement dangereux du CYP3A4. Une revue de 2002 de la recherche sur le modafinil pour le traitement des troubles du sommeil liГ©s au travail postГ© a rapportГ© "une nette supГ©rioritГ©" du modafinil par rapport au placebo, montrant des amГ©liorations des symptГґmes des troubles du sommeil liГ©s au travail postГ© qui Г©taient "cliniquement significatives". Le modafinil a un statut GRAS, ou gГ©nГ©ralement reconnu comme sГ»r, aux Г‰tats-Unis. Le modafinil est un stimulant du systГЁme nerveux central (SNC) et agit principalement comme un stimulant non amphГ©tamine. Depuis son apparition sur le marchГ© amГ©ricain, le modafinil est prГ©sentГ© comme un В« mГ©dicament intelligent В». La concentration maximale dans le plasma est atteinte en 8 heures environ. En 2019, il n'y avait aucun lien connu entre d'autres mГ©dicaments utilisГ©s pour le traitement de la narcolepsie et la dГ©pendance, la surconsommation, l'abus ou le suicide. Il semble agir en affectant la production de divers neurotransmetteurs dans le cerveau et semble augmenter la dopamine, la noradrГ©naline et la sГ©rotonine. Il a Г©tГ© dГ©montrГ© que le modafinil fonctionne mieux chez les personnes atteintes du syndrome des jambes sans repos ou d'affections similaires dues Г une carence en dopamine. On pense que le modafinil stimule directement la production d'AMPc (adГ©nosine monophosphate cyclique), qui produit ses effets stimulants.
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Les effets du modafinil sont observés en 30 minutes environ, les premiers effets notables sur la vigilance survenant environ 1 heure après la prise de la dose. La durée d'action du médicament est inférieure à 6 heures lorsqu'il est administré une fois par jour. Elle ajoute : « Cet effet est assez fort chez les animaux. Il est environ 95 % aussi puissant que l'amphétamine ou la phentermine dans des modèles animaux. Le modafinil est aussi parfois appelé un article de prescription "à volonté". Le modafinil peut être disponible sous des formes génériques, de marque et de marque maison. Les taux sanguins de modafinil culminent 3 à 6 heures après l'administration et diminuent rapidement par la suite. Une dose plus lente de 200 mg une fois par jour est recommandée pour les patients pédiatriques et les jeunes adultes. Les participants à l'étude ayant des antécédents de trouble du travail posté ont été divisés en groupes et ont reçu un placebo ou du modafinil dans deux études distinctes. Pour éviter cela, les personnes qui prennent le médicament doivent éviter de faire des siestes, de faire de l'exercice, de manger des repas copieux ou de boire de l'alcool. En 2018, cela semblait être un effet secondaire rare et des conseils sur le médicament sont disponibles en ligne. Le modafinil est un médicament stimulant avec un début rapide et une courte durée d'action dans le SNC, et peut être pris en cas de besoin. Des problèmes neurologiques tels que des hallucinations et des mouvements musculaires anormaux peuvent survenir, en particulier chez les personnes ayant des antécédents de psoriasis et de dépression.
modafinil canada L'innocuitГ© et l'efficacitГ© du modafinil pour ces utilisations hors indication ne sont pas concluantes et des recherches supplГ©mentaires sont nГ©cessaires. Il est utilisГ© pour diminuer les symptГґmes de somnolence temporaire causГ©s par de mauvaises habitudes de sommeil ou un travail postГ©. Le mГ©dicament est utilisГ© principalement pour traiter la somnolence excessive due Г la narcolepsie et aux troubles du sommeil liГ©s au travail postГ©. Le modafinil est utilisГ© en mГЄme temps dans une journГ©e comme stimulant car il aide Г prГ©venir la somnolence, augmente la vigilance et diminue la fatigue tout au long de la journГ©e. Il est prescrit pour une utilisation dans le traitement de la maladie de Parkinson, y compris le traitement des symptГґmes de carence en dopamine. Prise sous sa forme la plus couramment utilisГ©e, c'est une amphГ©tamine de synthГЁse. Il a Г©galement Г©tГ© utilisГ© hors AMM pour amГ©liorer l'Г©veil dans des Г©tudes animales et humaines. La quantitГ© exacte de Modafinil que les gens devraient prendre pour ressentir un effet est variable. Il peut Г©galement amГ©liorer la mГ©moire et la concentration. Une fois que le mГ©dicament a Г©tГ© dГ©couvert, il a rapidement Г©tГ© retirГ© de l'utilisation clinique car il provoquait une rigiditГ© sГ©vГЁre de la mГўchoire, y compris l'Г©rosion permanente de l'os. Si vous le prenez pendant plus de deux semaines, parlez-en Г votre mГ©decin. Il a la capacitГ© de mГ©dier les fonctions Г©motionnelles et cognitives. L'inhibition de la recapture de l'adГ©nosine bloque Г©galement les effets de la stimulation naturelle du cerveau, qui est un facteur contribuant Г la somnolence. Il s'agit d'un antagoniste sГ©lectif, non sГ©lectif et rГ©versible d'un seul sous-type neuronal d'un type de molГ©cule de neurotransmetteur inhibiteur appelГ©e rГ©cepteurs D2. Il bloque la recapture de la dopamine.
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