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06-22-2023, 11:38 PM
(This post was last modified: 06-22-2023, 11:39 PM by Le Modafinil.)
La Drug Enforcement Administration des États-Unis a classé le modafinil comme une substance contrôlée de l'annexe IV. Il est disponible uniquement sur ordonnance aux États-Unis. Les effets du modafinil sur les neurotransmetteurs dopamine, noradrénaline et sérotonine sont quelque peu minimes. Le modafinil peut augmenter la capacité naturelle d'une personne à dormir. Il arrête temporairement les signaux que le cerveau envoie au corps lorsque le corps pense qu'il devrait dormir. Cette action peut être responsable de ses effets plus ciblés. Le modafinil est métabolisé par le foie. Prenez le modafinil à la même heure chaque jour. Le modafinil se lie à une protéine appelée transporteur de la dopamine et de la noradrénaline (DAT) et diminue la disponibilité de la dopamine et de la noradrénaline dans le cerveau. Il est généralement bien toléré, bien qu'il ait été associé à des effets indésirables tels que des hallucinations et des changements de comportement et plus rarement à une hypotension, une anorexie et une arythmie cardiaque (par exemple, une hyperkaliémie). Il est plus efficace que les placebos. Le modafinil a été développé par le neuroscientifique français Michel Jouvet et les laboratoires Lafon pour traiter les symptômes de la narcolepsie. Dose initiale recommandée de 75 mg par jour, avec augmentation progressive de la dose (25 mg/jour tous les deux jours) jusqu'à 150 mg par jour sur une période de trois à quatre jours, pour la somnolence cible. Modafinil n'est pas approuvé pour toutes les utilisations. nootropique achat C'est un stimulant à action centrale qui agit via plusieurs systèmes de récepteurs. La posologie la plus courante pour les adultes est de 200 mg une fois par jour. Il est généralement pris avec de la nourriture. Le modafinil stimule l'éveil sans augmenter la vigilance, ce qui en fait un traitement utile pour les travailleurs postés. Le modafinil est généralement pris trois fois par jour. Les recommandations posologiques courantes sont de 100 à 200 mg trois fois par jour, avec certaines preuves que des doses plus élevées, 200 à 400 mg trois fois par jour, sont plus efficaces pour améliorer les performances cognitives. Le modafinil est une poudre cristalline blanche qui peut être prise par voie orale. Avalez la gélule entière avec un verre d'eau. Modalert (nom commercial au Canada) et Provigil (nom commercial aux États-Unis) sont les noms d'un composé pharmacologique initialement appelé « A200 » dans le cadre d'un projet universitaire et fabriqué plus tard sous le nom de Nuvigil. Le modafinil est détectable jusqu'à 3 jours après l'arrêt de son utilisation. Bien que le médicament soit disponible pour une utilisation à court terme en tant que traitement de la narcolepsie, son utilisation à cette fin n'est pas approuvée par la Food and Drug Administration (FDA).
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Il a Г©galement Г©tГ© suggГ©rГ© que le modafinil pourrait avoir des effets d'amГ©lioration cognitive, ainsi qu'attГ©nuer les symptГґmes de la dГ©pression, du trouble dГ©ficitaire de l'attention avec hyperactivitГ© (TDAH), du trouble bipolaire et d'autres maladies mentales. Il n'y a pas suffisamment de preuves pour soutenir l'utilisation du modafinil chez les personnes atteintes de TDAH ou de troubles des conduites. Le modafinil n'est pas un traitement appropriГ© pour les troubles du sommeil associГ©s Г un problГЁme mГ©dical. En Europe, il est approuvГ© pour la cataplexie, une somnolence excessive d'origine mГ©dicamenteuse. Le modafinil ne doit pas ГЄtre pris plus d'une fois par jour Г fortes doses, il est donc gГ©nГ©ralement utilisГ© Г faible dose. Il n'a pas Г©tГ© approuvГ© pour le traitement du TDAH et les Г©tudes n'ont pas montrГ© d'efficacitГ© pour le traitement du TDAH. Les neurotransmetteurs dopamine et norГ©pinГ©phrine sont libГ©rГ©s au niveau des synapses; le modafinil bloque la recapture de ces neurotransmetteurs dans les fentes synaptiques. La dose suggГ©rГ©e de modafinil pour une personne de 400 Г 500 kg est de 100 Г 200 mg pris une heure avant le coucher, bien que cela puisse devoir ГЄtre ajustГ© en fonction du poids du patient. Au Royaume-Uni, il s'agit d'un mГ©dicament dГ©livrГ© uniquement sur ordonnance. La dose habituelle de modafinil pour les enfants est de 100 Г 200 mg/jour. Par consГ©quent, Modafinil peut changer votre humeur. La conduite automobile et les autres activitГ©s sensibles Г la sГ©curitГ© doivent ГЄtre Г©vitГ©es jusqu'Г ce que les effets du mГ©dicament soient connus. Il agit comme un neurotransmetteur dans le cerveau pour affecter l'Г©veil et le sommeil. nootropique achat L'Г©tude a rГ©vГ©lГ© que les comprimГ©s provoquaient un pourcentage plus Г©levГ© d'utilisateurs В« alertes В» que de se rГ©veiller avec moins de somnolence (Wolkowitz 2004). Les concentrations plasmatiques maximales sont atteintes aprГЁs environ 3 heures et la demi-vie du modafinil est d'environ 3,5 heures aprГЁs une dose unique de 200 mg. De rares rГ©actions dermatologiques graves peuvent survenir chez les personnes prГ©sentant des prГ©dispositions gГ©nГ©tiques et plus frГ©quemment chez les patients pГ©diatriques. Le modafinil est un stimulant du systГЁme nerveux central (SNC). Cela rend une personne moins fatiguГ©e pendant le sommeil, l'aidant ainsi Г obtenir un sommeil plus rГ©parateur. Le modafinil est Г©galement disponible sous forme liquide et en spray nasal. Le modafinil est disponible sous forme de comprimГ©s oraux de 10 Г 200 mg, avec une seule marque disponible aux Г‰tats-Unis. La posologie est gГ©nГ©ralement comprise entre 200 mg et 400 mg par jour, et est augmentГ©e Г 300 mg ou 400 mg. Le modafinil est Г©galement dГ©conseillГ© aux personnes prenant des mГ©dicaments pouvant causer des problГЁmes de foie et ne doit pas ГЄtre pris avec d'autres mГ©dicaments qui doivent ГЄtre mГ©tabolisГ©s par le foie. Alors que l'utilisation est associГ©e Г certains avantages cognitifs, les effets secondaires limitent son efficacitГ© pour cette utilisation. En 1998, deux Г©quipes de recherche ont identifiГ© cinq Г©tudes dans la littГ©rature scientifique Г©valuГ©e par des pairs qui ont Г©tudiГ© l'effet du Modafinil sur la cognition.
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