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[Le Modafinil]

Les Г©vГ©nements indГ©sirables peuvent inclure des maux de tГЄte, des troubles du sommeil et des nausГ©es. Le modafinil est aussi parfois appelГ© inhibiteur sГ©lectif de la recapture de la sГ©rotonine, ou ISRS. Les mГ©dicaments sont fabriquГ©s par quelque 22 entreprises dans plus de 15 pays. L'une des formes de modafinil est le modafinil xr, une version Г  libГ©ration prolongГ©e une fois par jour du mГ©dicament qui permet de rester Г©veillГ© pendant 24 heures. Il est commercialisГ© comme traitement des troubles du sommeil liГ©s au travail postГ© et de la somnolence excessive. Cependant, il n'est pas recommandГ© par la FDA pour une utilisation comme activateur cognitif. On ne sait pas si l'utilisation pendant la grossesse est sans danger. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension importante ou d'hypertrophie ventriculaire gauche. Le modafinil semble activer ces zones cГ©rГ©brales avec moins d'effets secondaires que l'amphГ©tamine et d'autres agents favorisant l'Г©veil. Ces comprimГ©s sont blancs, ronds et de forme irrГ©guliГЁre. Bien qu'il soit vendu Г  la fois en version gГ©nГ©rique et de marque aux Г‰tats-Unis, l'Union europГ©enne n'a approuvГ© que le modafinil gГ©nГ©rique, tandis que les Г‰tats-Unis n'ont approuvГ© que le nom de marque. La dose optimale de modafinil pour amГ©liorer les performances de la mГ©moire de travail et de l'attention est la dose de 200 Г  400 mg, prise Г  la mГЄme heure chaque jour. La sГ©curitГ© du modafinil pendant la grossesse n'est pas bien Г©tablie. En avril 2016, le modafinil a Г©tГ© approuvГ© pour le traitement de la somnolence excessive chez les patients souffrant d'apnГ©e obstructive du sommeil, en plus de son indication approuvГ©e. Contrairement aux stimulants de type amphГ©tamine, le modafinil prГ©sente un faible potentiel d'abus, de dГ©pendance ou de symptГґmes de sevrage. modafinil generique Dans un vaste essai de 82 participants, il a Г©tГ© dГ©montrГ© qu'il amГ©liorait le sommeil et les performances lorsqu'il Г©tait pris la nuit avant un long quart de travail ou aprГЁs le rГ©veil au service actif dans l'armГ©e. Il amГ©liore le systГЁme de neurotransmetteur dopaminergique. Le modafinil est principalement utilisГ© pour traiter divers troubles du sommeil, notamment la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil. Le modafinil semble Г©galement augmenter la disponibilitГ© de certains produits chimiques activateurs cognitifs appelГ©s В«sГ©rotonineВ» dans le cerveau, ce qui peut amГ©liorer la cognition. Il subit une biotransformation modГ©rГ©e Г  complГЁte dans le foie en mГ©tabolite actif N-desmГ©thylmodafinil. Les Г©vГ©nements indГ©sirables peuvent inclure des maux de tГЄte, des troubles du sommeil et des nausГ©es. Son efficacitГ© est discutable en raison du manque de preuves dans ce domaine. Le modafinil est pris par voie orale et la posologie est basГ©e sur le poids corporel. L'un des mГ©canismes du modafinil consiste Г  inhiber l'enzyme alanine aminotransfГ©rase. La dose d'entretien quotidienne peut aller jusqu'Г  600 mg, sans limite quotidienne. Le modafinil est frГ©quemment utilisГ© pour traiter les troubles du sommeil, tels que l'apnГ©e du sommeil. Le modafinil est un mГ©dicament sur ordonnance disponible aux Г‰tats-Unis, oГ№ il peut ГЄtre prescrit par des mГ©decins et obtenu lГ©galement avec un identifiant de patient attribuГ© et un numГ©ro de programme de surveillance des mГ©dicaments sur ordonnance (PDMP). Le modafinil peut gГ©nГ©ralement ГЄtre pris sans danger avec ou sans nourriture.

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Le modafinil est un indazole N-dГ©mГ©thylГ© et la BENZODiazГ©pine. L'adГ©nosine est liГ©e au sommeil. Le modafinil est Г©galement produit par Apex Laboratories (Canada), Immodafinil (Canada) et Neurotin Labs (Canada). Le modafinil est un exemple de mГ©dicament stimulant, normalement utilisГ© pour amГ©liorer l'Г©veil chez les personnes souffrant de somnolence chronique due Г  la narcolepsie, aux troubles du sommeil liГ©s au travail postГ© et Г  l'apnГ©e obstructive du sommeil. On pense que l'adГ©nosine atteint le cerveau principalement par la barriГЁre hГ©mato-encГ©phalique, bien qu'elle soit Г©galement produite dans le cerveau et puisse ГЄtre libГ©rГ©e sous forme de substances endogГЁnes, telles que le N-acГ©tyl-l-aspartate (NAA). Les patients doivent noter l'heure exacte Г  laquelle la dose est prise, car cela permet de dГ©terminer dans quelle mesure le mГ©dicament est efficace et dans quelle mesure la dose est nГ©cessaire. En 1999, Nature Biotechnology a publiГ© une recherche qui a montrГ© que le Modafinil ne stimulait pas directement les cellules hypocrГ©tines, et la recherche de Jouvet a ensuite Г©tГ© discrГ©ditГ©e. Le mГ©canisme d'action du mГ©dicament n'est pas bien compris. Il peut s'agir d'un neuroamplificateur encore plus efficace que l'amphГ©tamine, des Г©tudes suggГ©rant qu'il est plus efficace pour induire une amГ©lioration de la mГ©moire de travail Г  long terme que l'amphГ©tamine. Il est classГ© comme mГ©dicament stimulant. Des Г©tudes ont Г©galement indiquГ© qu'il peut aider Г  restaurer la vigilance chez les personnes atteintes de troubles cognitifs lГ©gers, de dГ©mence et de la maladie de Parkinson. Le modafinil n'est pas une drogue de rue illicite aux Г‰tats-Unis. La dose appropriГ©e pour les adultes chez qui une durГ©e d'action plus courte est nГ©cessaire est de 100 mg ou 200 mg selon l'indication pour laquelle elle est prescrite. modafinil generique Il est utilisГ© pour traiter les symptГґmes d'une hygiГЁne de sommeil inadГ©quate dans l'environnement domestique, en particulier la difficultГ© Г  s'endormir, le rГ©veil tГґt le matin et la sensation de fatigue au rГ©veil. Le modafinil est Г©galement dГ©conseillГ© aux personnes souffrant d'arythmie, d'hypertension artГ©rielle importante ou d'hypertrophie ventriculaire gauche. Dans l'autre Г©tude, ils ont Г©tГ© augmentГ©s de 15 % dans les noyaux caudГ©s et de 27 % dans le cortex prГ©frontal, un changement positif associГ© Г  une augmentation de l'Г©veil. Les deux essais ont recrutГ© des volontaires sains ayant des antГ©cГ©dents de troubles du sommeil. Certaines personnes peuvent prГ©senter des rГ©actions allergiques ou autres telles que l'anaphylaxie pouvant inclure des douleurs abdominales, de la diarrhГ©e, des difficultГ©s respiratoires, de l'urticaire et un Е“dГЁme de Quincke. Dans ce rГґle, l'acГ©tylcholine amГ©liore la libГ©ration de norГ©pinГ©phrine des terminaisons nerveuses sympathiques et favorise la libГ©ration de dopamine des systГЁmes extrapyramidal (substantia nigra) et mГ©solimbique (tГ©gmental ventral). Il est Г©galement utilisГ© comme stimulant cognitif pour les patients atteints de sclГ©rose en plaques. Il augmente Г©galement la mГ©latonine et la prolactine. Med Hypoth Sci. Le modafinil est disponible en tant que mГ©dicament gГ©nГ©rique. Le modafinil augmente l'activitГ© de la dopamine dans le systГЁme limbique du cerveau et peut Г©galement augmenter l'activitГ© de la sГ©rotonine. Les bienfaits du modafinil peuvent durer plus de 48 heures et sont particuliГЁrement Г©vidents aprГЁs 12 heures.

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