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[Le Modafinil]

Le modafinil a également été largement utilisé comme améliorateur de performances sportives. Le modafinil est approuvé par la FDA pour le traitement de la narcolepsie, des troubles du sommeil liés au travail posté et de l'apnée obstructive du sommeil. Le modafinil est un antagoniste des récepteurs de la vasopressine et bloque l'action de la vasopressine. Le mécanisme d'action précis du modafinil est inconnu. Son mode d'action dans le système nerveux central est le même que celui d'autres stimulants, comme la caféine et les amphétamines. Les chercheurs ont administré 100 mg de modafinil aux participants. Les utilisations hors AMM les plus courantes du modafinil incluent des rapports d'amélioration de la vigilance chez des personnes par ailleurs en bonne santé. Dans certains cas, une somnolence excessive survient à la suite d'une condition médicale telle que la narcolepsie. Modafinil est disponible uniquement sur ordonnance. Il a également été démontré que 400 et 600 mg réduisent la somnolence excessive associée à la narcolepsie avec cataplexie. Les effets secondaires rares et graves peuvent inclure des réactions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antécédents de psychose. Il a également été suggéré comme un acteur possible de la mémoire. provigil belgique Il a été démontré que l'utilisation hors AMM chez les humains et les animaux augmente la vigilance et améliore le rappel de la mémoire. Il se décline en plusieurs points forts. La demi-vie apparente moyenne est de 2,8 heures. Le modafinil agit en inhibant la recapture de la dopamine dans le cerveau, ce qui entraîne une augmentation de la concentration du neurotransmetteur dans l'espace synaptique. Le modafinil a fait l'objet de nombreuses études scientifiques, bien qu'il n'apparaisse généralement pas dans la plupart des manuels de psychiatrie. Le modafinil est un agoniste alpha-adrénergique sélectif et a une courte durée d'action avec une demi-vie d'environ 6 heures et une durée d'action entre 12 et 24 heures. Le modafinil bloque ces récepteurs, ce qui entraîne une augmentation de l'éveil. Il a été démontré qu'il s'agit d'un médicament relativement sûr, avec peu ou pas d'effets secondaires négatifs. Certaines personnes peuvent également avoir des réactions allergiques. Le modafinil est un médicament sur ordonnance disponible sous forme de comprimés et de gélules. Il a été développé pour la première fois dans les années 1970 par les scientifiques Michel Jouvet, neurophysiologiste de l'Université de Paris, et Pierre Tabouillot, biochimiste français. Un métabolite actif du modafinil, le desméthyl-modafinil, était également efficace pour améliorer l'éveil, en particulier chez les personnes atteintes de narcolepsie. Le modafinil est une indolalkylamine.

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[wolfsone]

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