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Par exemple, la prescription de modafinil doit ГЄtre accompagnГ©e de prГ©cautions quant au risque de syndrome malin des neuroleptiques. Un petit nombre d'Г©tudes sur le modafinil chez des adultes normaux en bonne santГ©, utilisant des doses similaires Г  celles utilisГ©es pour la narcolepsie et les troubles du sommeil liГ©s au travail postГ©, ont trouvГ© des amГ©liorations modГ©rГ©es de la fonction exГ©cutive Г  des doses beaucoup plus importantes. Bien que l'on pense gГ©nГ©ralement qu'il s'agit du mГЄme mГ©dicament que celui avec lequel il a Г©tГ© dГ©veloppГ©, il a considГ©rablement changГ© dans sa structure chimique, son mode de synthГЁse, sa mГ©thode de production, sa distribution, son utilisation et son efficacitГ©. Le modafinil est un stimulant sГ©lectif du systГЁme nerveux central (SNC). Le modafinil est gГ©nГ©ralement pris par voie orale le matin, seul ou avec de la nourriture. Elle affecte les zones du cerveau impliquГ©es dans la motivation, la vigilance et la concentration. Cela signifie que le dosage requis pour un effet particulier sera diffГ©rent du dosage requis pour un autre effet. Il ne crГ©e pas de dГ©pendance et ne produit pas d'effets indГ©sirables chez les personnes souffrant d'hypothyroГЇdie. Il est gГ©nГ©ralement utilisГ© avant d'aller au lit. Le trouble du sommeil liГ© au travail postГ© est un trouble du sommeil dans lequel le corps veut dormir Г  des moments inappropriГ©s (c'est-Г -dire pendant que vous ГЄtes censГ© travailler). Des doses de 400 Г  600 mg sont recommandГ©es dans la narcolepsie. modafinil belgique Bien que classГ© comme nootropique, le terme В«nootropiqueВ» est destinГ© Г  dГ©crire les amГ©liorations de la mГ©moire, de l'apprentissage et de la concentration. En 2005, Terri Young, une mГЁre de trois enfants des Г‰tats-Unis, a intentГ© une action en justice contre le fabricant aprГЁs que son fils, Stephen, se soit vu prescrire du modafinil pour traiter la narcolepsie. Certaines Г©tudes ont Г©galement montrГ© qu'il peut aider Г  traiter la dГ©pression modГ©rГ©e, mais qu'il peut ГЄtre au moins deux fois plus susceptible de provoquer des effets secondaires qu'un placebo Г  cet Г©gard, tels que nausГ©es, insomnie et anxiГ©tГ©. On pense que le modafinil crГ©e moins de tolГ©rance que la cafГ©ine. Il a Г©tГ© dГ©montrГ© que le modafinil rГ©duit la gravitГ© et l'incidence des troubles du sommeil liГ©s au travail postГ©. Le modafinil n'est pas destinГ© Г  ГЄtre utilisГ© par des personnes souffrant de dГ©calage horaire ou qui ne souffrent pas de troubles du sommeil, et il est conseillГ© aux personnes atteintes de lГ©sions cГ©rГ©brales de consulter leur mГ©decin avant utilisation. Aucun mГ©canisme clair d'amГ©lioration cognitive n'a Г©tГ© dГ©couvert. Le modafinil est un stimulant non opioГЇde du systГЁme nerveux central qui rГ©duit la somnolence tout au long de la journГ©e et produit moins de somnolence diurne que la cafГ©ine, bien que ses effets sur la somnolence soient plus progressifs et durent gГ©nГ©ralement plus longtemps que ceux de la cafГ©ine. L'ingrГ©dient actif est le mГ©dicament pharmaceutique connu sous le nom de modafinil (50 mg) ou N-desmГ©thyl modafinil (100 mg, 200 mg, 300 mg) et L-desmГ©thyl modafinil (50 mg, 100 mg, 200 mg). On pense Г©galement que les effets du modafinil sont liГ©s Г  l'histamine et Г  son systГЁme rГ©cepteur. Le modafinil est un agent actif par voie orale et la version gГ©nГ©rique de Provigil. Sa formule molГ©culaire est C14H17ClN3O2S. Ce mГ©dicament a une gamme d'avantages qui le rend utile dans de nombreuses situations. Il est utilisГ© pour diminuer les symptГґmes de somnolence temporaire causГ©s par de mauvaises habitudes de sommeil ou un travail postГ©. Le modafinil a une courte demi-vie.

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Le modafinil empГЄche certains types de stimulants d'atteindre le cerveau. Il est disponible sur ordonnance aux Г‰tats-Unis. Le modafinil n'a pas amГ©liorГ© le nombre de rГ©veils, de sommeil pendant la journГ©e ou le nombre de quarts de travail nГ©cessaires pour contrГґler la somnolence. Premier mГ©dicament approuvГ© par la FDA amГ©ricaine pour le traitement de la В« somnolence excessive В», le modafinil a Г©tГ© vendu sous le nom commercial Provigil par Alza aux Г‰tats-Unis et sous le nom commercial Modavigil par GlaxoSmithKline au Canada. Il est utilisГ© dans le traitement du TDAH chez les enfants et les adultes depuis le dГ©but des annГ©es 1980. Le modafinil est gГ©nГ©ralement bien tolГ©rГ©, avec des effets secondaires possibles, notamment des maux de tГЄte, des troubles du sommeil et des nausГ©es. On pense que le modafinil a une faible affinitГ© pour les rГ©cepteurs de l'histamine (H1), les rГ©cepteurs de la dopamine (D2 et D4) et une affinitГ© substantielle pour les rГ©cepteurs de l'adГ©nosine. Le modafinil, qui est Г©galement vendu sous le nom de Provigil, est une poudre cristalline blanche Г  blanc cassГ© avec un goГ»t sucrГ© inodore ou lГ©gГЁrement parfumГ©. Le modafinil a une demi-vie d'environ 6 heures, mais ses effets neurochimiques persistent pendant au moins 10 heures. Un essai clinique dГ©finitif (CAMPT) a Г©tГ© publiГ© en 2009 et a rГ©vГ©lГ© que le modafinil Г©tait associГ© Г  une augmentation de l'Г©veil par rapport au placebo chez les personnes souffrant d'apnГ©e du sommeil. modafinil belgique Г‡a n'a pas de goГ»t. Le modafinil est largement mГ©tabolisГ©, avec plus de 90 % du mГ©dicament mГЁre mГ©tabolisГ© par trois voies, impliquant les enzymes du cytochrome P450 (CYP). Le modafinil augmente les niveaux cГ©rГ©braux de dopamine et d'acГ©tylcholine, tout en diminuant les niveaux de noradrГ©naline. Il n'est pas clair si l'utilisation pendant la grossesse est sans danger. Il a Г©tГ© dГ©montrГ© que le modafinil rГ©duit la somnolence chez les sujets sains et chez ceux souffrant de narcolepsie. Des rapports d'effets secondaires graves (y compris des rГ©actions allergiques potentiellement mortelles) chez certaines personnes dans des Г©tudes cliniques ont conduit Г  des avertissements pour l'utilisation du modafinil. Il a Г©galement Г©tГ© utilisГ© pour le traitement du syndrome des jambes sans repos (SJSR) chez les adultes et les enfants. Le modafinil a Г©tГ© utilisГ© chez les animaux dans des Г©tudes oГ№ il a semblГ© amГ©liorer l'Г©veil d'une maniГЁre plus diversifiГ©e qu'avec d'autres agents favorisant l'Г©veil. Le fabricant suggГЁre de prendre du modafinil entre 3 et 6 heures avant le coucher. Le modafinil est un mГ©dicament d'ordonnance approuvГ© aux Г‰tats-Unis comme traitement de la somnolence diurne chronique associГ©e Г  la narcolepsie et aux troubles du sommeil liГ©s au travail postГ©. Toutes les informations sur cette page concernant le modafinil proviennent du module d'information sur les mГ©dicaments de la National Library of Medicine.

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PremiГЁrement, il stimule la production d'hormones favorisant l'Г©veil. Le modafinil est utilisГ© pour traiter les troubles du sommeil liГ©s au travail postГ©, une condition dans laquelle les personnes travaillent pendant les heures normales de sommeil, mais ont du mal Г  dormir ou Г  s'endormir la nuit. Le modafinil est disponible en comprimГ©s de 50 mg, 100 mg et 150 mg. Le modafinil n'affecte pas la tension artГ©rielle, la frГ©quence cardiaque ou la tempГ©rature corporelle. Il affecte la voie de signalisation de la dopamine, qui est la cible principale des antidГ©presseurs, permettant Г  la dopamine supplГ©mentaire d'ГЄtre libГ©rГ©e dans l'espace synaptique entre les neurones, augmentant ainsi l'Г©veil. Le modafinil est un substrat pour les transporteurs d'efflux de mГ©dicaments, la glycoprotГ©ine P et la protГ©ine de rГ©sistance au cancer du sein. Au Royaume-Uni, il s'agit d'un mГ©dicament dГ©livrГ© uniquement sur ordonnance. La somnolence et la bouche sГЁche sont les effets indГ©sirables les plus courants du Modafinil. Le modafinil 200 mg est une bonne dose pour les personnes qui ont juste besoin de se rafraГ®chir le cerveau et le corps, par exemple avant de passer un examen. Le modafinil a Г©tГ© approuvГ© par la Food and Drug Administration des Г‰tats-Unis (USFDA) pour traiter la narcolepsie (avec ou sans cataplexie). Le modafinil augmente le flux sanguin vers le cerveau et le cЕ“ur, mais diminue le flux sanguin dans d'autres organes et dans la peau. L'acГ©tylcholine est un neurotransmetteur qui provoque l'activation des neurones. Le modafinil peut causer des maux de tГЄte ou des troubles du sommeil. Les donnГ©es concernant l'efficacitГ© de ce mГ©dicament pour d'autres utilisations se limitent Г  la recherche pour le traitement de troubles cognitifs tels que le TDAH. Il est gГ©nГ©ralement pris en une seule dose importante. modafinil belgique Il agit en ciblant les centres de rГ©gulation veille-sommeil du cerveau. Le modafinil est utilisГ© pour traiter la fatigue liГ©e au travail postГ©, la somnolence due Г  la narcolepsie et l'apnГ©e obstructive du sommeil. Son utilisation comme activateur cognitif est controversГ©e, et on rapporte Г©galement qu'il a un certain usage rГ©crГ©atif. En raison de ses propriГ©tГ©s stimulantes, le modafinil provoque une augmentation de la pression artГ©rielle, de la frГ©quence cardiaque et de la glycГ©mie. Il doit ГЄtre pris Г  la mГЄme heure chaque jour et seulement aprГЁs le petit-dГ©jeuner du matin. Le modafinil est le nom d'un inhibiteur sГ©lectif et rГ©versible de la recapture de la noradrГ©naline (NET). Il ne doit pas ГЄtre utilisГ© chez les personnes ayant des antГ©cГ©dents mГ©dicaux de schizophrГ©nie ou de troubles psychotiques de l'humeur, ou de trouble bipolaire. Avant de prendre le mГ©dicament, assurez-vous d'Г©crire une liste de tous les mГ©dicaments que vous prenez. Le modafinil affecte principalement le SNC et il n'est pas recommandГ© chez les personnes souffrant de maladies cardiovasculaires, d'arythmies, d'hypertension ou d'insuffisance hГ©patique. En gГ©nГ©ral, les personnes qui fument ou qui ont des antГ©cГ©dents de maladie du foie ou des reins peuvent ГЄtre plus sensibles au modafinil.

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