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06-23-2023, 08:40 PM
(This post was last modified: 06-23-2023, 08:41 PM by Le Modafinil .)
Il existe Г©galement une version gГ©nГ©rique vendue sous la marque Modalert. Il est Г©galement dГ©conseillГ© aux personnes atteintes d'hyperplasie de la prostate. Il peut Г©galement aggraver la progression d'autres affections telles que le diabГЁte, les maladies cardiaques et l'hГ©patite C. Le CYP2C19 a un rГґle mineur dans le mГ©tabolisme du modafinil. Il est utilisГ© hors AMM aux Г‰tats-Unis pour augmenter l'Г©veil chez certains individus. Il est dГ©conseillГ© aux personnes ayant des antГ©cГ©dents d'arythmie, d'hypertension ou de problГЁmes cardiovasculaires. Il est vendu sous plusieurs noms de marque, notamment Alertec, Arise, Cynapsine, Euclydon, Provigil, Unexamine et Zaricam. Le mГ©dicament est disponible sous forme de comprimГ©s et de sirop. Le modafinil est parfois conditionnГ© en flacons, mais il est plus communГ©ment vendu sous blister. Le modafinil est gГ©nГ©ralement bien tolГ©rГ©, avec des effets secondaires possibles, notamment des maux de tГЄte, des troubles du sommeil et des nausГ©es. La cimГ©tidine, la fluvoxamine, l'omГ©prazole, la rifampicine, la sertraline et la venlafaxine sont connues pour interagir potentiellement avec le modafinil. Dans une revue systГ©matique de l'efficacitГ© du modafinil pour l'amГ©lioration cognitive, les auteurs ont rapportГ© que la plupart des Г©tudes qui ont trouvГ© des rГ©sultats positifs l'ont fait dans le contexte de sous-ensembles de population prГ©sentant des vulnГ©rabilitГ©s spГ©cifiques.
modafinil C'est la voie de la dopamine impliquГ©e dans la motivation et la rГ©compense. Le modafinil a Г©tГ© approuvГ© en France en 1994 pour le traitement de la narcolepsie et d'autres troubles chroniques du sommeil, et pour sa capacitГ© Г rГ©duire la somnolence diurne causГ©e par le travail postГ©. Les informations sont insuffisantes pour Г©valuer son efficacitГ©. Le modafinil n'est pas indiquГ© pour le traitement de l'insomnie en soi. On pense que les effets durables du mГ©dicament sont dus Г sa capacitГ© Г rester dans le cerveau pendant plusieurs heures aprГЁs l'ingestion orale. Il contient l'ingrГ©dient actif modafinil. Le modafinil a Г©tГ© utilisГ© hors AMM comme prГ©tendu activateur cognitif pour amГ©liorer l'Г©veil dans des Г©tudes animales et humaines, mais son efficacitГ© Г cet Г©gard n'est pas prouvГ©e. Le modafinil est un agent nootropique, dГ©rivГ© du fruit africain modiocarpus tinctorius. Le modafinil peut interagir avec d'autres mГ©dicaments. La dose initiale habituelle pour la plupart des personnes souffrant de troubles du sommeil est de 50 Г 100 mg le matin, Г prendre Г la mГЄme heure chaque jour. Le mГ©dicament est disponible sous deux formes : aux Г‰tats-Unis, il est disponible sous forme de comprimГ© gГ©nГ©rique de modafinil de 150 mg. Le modafinil est un mГ©dicament d'Г©veil qui agit en augmentant l'activitГ© des neurones dans les parties du cerveau qui rГ©gulent la somnolence et l'Г©veil. L'ingrГ©dient actif dans les trois dosages est le modafinil.
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Le modafinil donne une sensation d'Г©veil et amГ©liore l'Г©nergie. Il est important de noter que la National Sleep Foundation dГ©finit quatre catГ©gories de somnolence : L'utilisation du modafinil est approuvГ©e aux Г‰tats-Unis par la Food and Drug Administration (FDA) des Г‰tats-Unis pour traiter la narcolepsie, les troubles du sommeil liГ©s au travail postГ© et l'apnГ©e obstructive du sommeil. Le mГ©canisme d'action complexe du modafinil n'est pas entiГЁrement connu, bien qu'en 2016, le Journal de l'American Medical Association ait publiГ© une Г©tude montrant que l'administration de Modafinil favorise l'Г©veil en inhibant le sommeil Г plusieurs niveaux, y compris le contrГґle des oscillations veille-sommeil, l'initiation et la consolidation du sommeil, et l'expression de l'horloge circadienne. Des effets indГ©sirables du modafinil ont Г©tГ© observГ©s dans des Г©tudes animales. Une revue de la littГ©rature de 2012 concernant le modafinil chez des individus en bonne santГ© a rapportГ© qu'il n'avait que des effets clairs sur l'endormissement et considГ©rait les effets sur la cognition et l'humeur plus discutables. D'autres formes de modafinil dont la vente n'est pas approuvГ©e aux Г‰tats-Unis comprennent les В« solutions В» de 200 mg et 400 mg et les comprimГ©s Г dissolution orale. Cependant, il a Г©tГ© dГ©montrГ© qu'il amГ©liore un certain nombre de fonctions liГ©es au sommeil et Г l'Г©veil, notamment la vigilance, l'attention, la mГ©moire et les fonctions exГ©cutives. Le modafinil inhibe Г©galement l'enzyme qui dГ©compose l'adrГ©naline (Г©pinГ©phrine). Les effets secondaires graves du modafinil sont rares et comprennent des hallucinations, des sautes d'humeur graves, une psychose, une frГ©quence cardiaque rapide et des rГ©actions allergiques graves. Les patients souffrant de troubles mentaux, de maladies cardiaques et de maladies du foie ou des reins sont particuliГЁrement vulnГ©rables. Le modafinil est Г©galement disponible sous une forme microcristalline qui ne nГ©cessite pas de remplissage de capsule ni d'administration orale. Les patients qui ont pris du modafinil ont continuГ© Г se sentir plus alertes pendant la journГ©e que ceux sous placebo.
modafinil Dans le cortex, la dopamine module les mГ©canismes qui rГ©gulent le sommeil et l'Г©veil. Les mГЄmes prГ©cautions sont appliquГ©es aux personnes atteintes de phГ©nylcГ©tonurie (PCU). Le modafinil est un modulateur allostГ©rique positif sГ©lectif du rГ©cepteur GABAA. On dit aussi qu'il augmente la bonne humeur et le bonheur gГ©nГ©ral. Modafinil a Г©tГ© vu pour augmenter les niveaux de NO dans le liquide cГ©phalo-rachidien. Le mГ©canisme d'action spГ©cifique est inconnu, mais le modafinil peut agir sur les zones du cerveau impliquГ©es dans le sommeil. En raison de ces mГ©canismes, le modafinil a le potentiel d'augmenter l'Г©veil. Le modafinil n'est pas recommandГ© chez les personnes souffrant d'anГ©mie. Cela peut Г©galement aider Г amГ©liorer la mГ©moire chez certaines personnes. L'un des ingrГ©dients actifs du modafinil est le N-acГ©tyl-rГ©-lysine (ADL), un modulateur des rГ©cepteurs de l'histamine et de l'acГ©tylcholine, et l'implication de la voie dopaminergique dans l'effet favorisant l'Г©veil du mГ©dicament n'ont Г©tГ© dГ©couvertes que dans les annГ©es 2000. Il est distribuГ© dans le corps et est rapidement mГ©tabolisГ©. Les effets secondaires courants du modafinil Г libГ©ration prolongГ©e comprennent l'agitation, l'anxiГ©tГ©, les hallucinations et les convulsions.
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Comme d'autres stimulants, le modafinil stimule la synthèse et la libération de noradrénaline et de dopamine dans le cerveau. Il est cependant disponible en vente libre dans un certain nombre de pays où il a été approuvé pour une utilisation dans le traitement de troubles du sommeil spécifiques. Le modafinil est également utilisé pour traiter l'épilepsie partielle bénigne de l'enfance avec des pointes (les garçons atteints de cette maladie peuvent éprouver des épisodes de somnolence diurne excessive qui peuvent être traités avec le médicament). Bien qu'aucune étude de grande envergure n'ait été réalisée sur l'efficacité du modafinil pour la perte de poids ou à d'autres fins thérapeutiques, un examen des preuves en 2012 a indiqué que l'explication la plus probable des effets antidépresseurs et anti-anxiété du modafinil est la régulation des neurotransmetteurs et des circuits neuronaux correspondants. Le modafinil agit en augmentant les niveaux de dopamine et de noradrénaline dans le cerveau. Modafinil est un mélange racémique et a une formule empirique de C12H11NOS. Le terme Modafinil est une forme abrégée de chlorhydrate de modafinil, un principe actif aigu du règne végétal. La majorité des recherches sur l'utilisation du modafinil chez l'homme ont porté sur des personnes qui travaillent par quarts, celles qui souffrent d'apnée obstructive du sommeil et celles qui souffrent de narcolepsie. Sous les noms de marque Acolyte, Ritalin-ML et Modavigil, il est également disponible sous forme de médicament générique. D'autres médicaments peuvent interagir avec le modafinil et augmenter ses effets secondaires. Comme les autres stimulants, il a une demi-vie de 5 à 7 heures.
modafinil Le modafinil fonctionne bien avec l'alcool, car il peut augmenter la vigilance ou prГ©venir la somnolence. La sociГ©tГ© a dГ©veloppГ© le Modafinil pour traiter la narcolepsie, un trouble des cellules cГ©rГ©brales qui provoque une somnolence excessive. D'autres peuvent nГ©cessiter une sieste plus longue. Pour les personnes souffrant d'anorexie mentale, il est recommandГ© de prendre 200 Г 400 mg deux fois par jour. Il est classГ© comme stimulant du systГЁme nerveux central (SNC). Le modafinil est Г©galement un dГ©rivГ© de l'imidazole. La consommation d'aliments et de cafГ©ine pendant la prise de modafinil peut rГ©duire son efficacitГ© et doit donc ГЄtre Г©vitГ©e. La durГ©e habituelle du traitement est de 7 jours. Une substance similaire, l'amphГ©tamine, avait dГ©jГ Г©tГ© utilisГ©e comme stimulant dans les annГ©es 1970 par des chercheurs en toxicomanie, et le Modafinil a Г©tГ© dГ©veloppГ© pour ГЄtre 10 fois moins stimulant. Est dГ©conseillГ© aux personnes ayant des antГ©cГ©dents de psychose. NГ©anmoins, la puretГ© du modafinil serait gГ©nГ©ralement supГ©rieure Г 99 %. Le modafinil a Г©tГ© approuvГ© sur la base de sa capacitГ© Г amГ©liorer l'Г©veil, et a ensuite Г©tГ© autorisГ© pour le traitement des troubles du rythme circadien du sommeil. Les comprimГ©s de modafinil de 200 milligrammes sont blancs, sГ©cables, ronds et lГ©gГЁrement crayeux.
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