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Modafinil (Provigil) Modafinil (Modalert, Provigil), est utilisГ© comme activateur cognitif pour des indications mГ©dicales spГ©cifiques. La dose recommandГ©e est celle d'un traitement pour la journГ©e (par opposition Г  la durГ©e d'une journГ©e spГ©cifique) car une dose unique de plus de 200 mg peut entraГ®ner une perte de contrГґle. L'alprazolam, l'ingrГ©dient actif de XANAX, est Г©galement un composant de certains types de modafinil. MalgrГ© la recommandation courante de 100 mg, il s'agit d'un sous-dosage si le comprimГ© est pris en une seule prise. Les chercheurs ont dГ©couvert que ceux qui prenaient du modafinil montraient plus d'activitГ© pendant la journГ©e, plus de vigilance globale et moins de somnolence pendant la nuit. Le modafinil est un activateur de l'Г©veil, utilisГ© pour traiter les troubles du sommeil tels que la narcolepsie, la somnolence diurne excessive due au travail postГ© et l'hypersomnie idiopathique. Nootropique En France Un maximum de trois doses quotidiennes peut ГЄtre utilisГ© par jour. Le modafinil n'est pas une substance contrГґlГ©e aux Г‰tats-Unis et est disponible sans ordonnance. Son mГ©canisme d'action n'a pas Г©tГ© entiГЁrement Г©lucidГ©, mais on pense qu'il implique la modulation des rГ©cepteurs de l'acide gamma-aminobutyrique et de la dopamine. Certaines Г©tudes suggГЁrent que le traitement par le modafinil amГ©liore les symptГґmes de la dГ©pression chez les patients souffrant de dГ©pression majeure qui ne rГ©pondent pas aux traitements standards. La dopamine est un neurotransmetteur associГ© Г  la rГ©compense. Le modafinil se lie au rГ©cepteur de la dopamine D3 dans le cerveau. La dose quotidienne habituelle pour un traitement intermittent varie de 100 Г  400 mg. Il a Г©tГ© rapportГ© que l'utilisation hors AMM du modafinil augmentait la vigilance, l'Г©veil et la vigilance chez les personnes souffrant de troubles du sommeil. Comme il agit sur le cortex prГ©frontal, il peut y avoir une certaine altГ©ration de la chimie du cerveau. Le modafinil agit via le transporteur de la dopamine et augmente l'Г©veil. Le modafinil a un taux sГ©rique cible de 20 mcg/mL, ce qui Г©quivaut Г  25 mcg/g et est atteint avec 400 mg. Le citrate de modafinil (ou modafinil HCl) peut ГЄtre pris sans tenir compte des repas et peut ГЄtre pris sous forme de comprimГ© ou de liquide, et sa nature IR signifie qu'il peut ГЄtre rapidement absorbГ© et commence Г  agir peu de temps aprГЁs l'ingestion. La demi-vie du modafinil est d'environ 1,5 Г  4 heures, selon la forme et la posologie.

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Le modafinil semble fonctionner en augmentant l'activité des récepteurs de la dopamine dans les neurones favorisant l'éveil du système nerveux central, en particulier ceux impliqués dans l'action de l'adénosine dans le cerveau. Il est également prescrit par les médecins pour traiter l'apnée obstructive du sommeil (AOS) lorsque les autres traitements n'ont pas fonctionné. Sa demi-vie est d'environ 3 à 5 heures et son métabolisme est très lent. Bien qu'il y ait un syndrome de sevrage après l'arrêt du médicament, il semble être léger. Le modafinil est disponible en comprimés de 500 mg, 150 mg et 100 mg. Nootropique En France Il est disponible en plusieurs dosages, chacun une fois par jour ou deux fois par jour. Également connu sous le nom de « Provigil » ou « nuvigil » dans certains pays, le modafinil est un stimulant du système nerveux central (SNC) utilisé pour traiter la somnolence due à la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. C'est dans les années 1980 qu'il a commencé à l'utiliser comme agent thérapeutique, mais Jouvet a écrit, "le modafinil n'a pas été à la hauteur des attentes". La recherche a été dirigée par le scientifique danois James Roth. Le modafinil est un stimulant non amphétamine qui n'a pas la capacité d'induire une dépendance psychologique, contrairement aux amphétamines. Bien que son mécanisme d'action exact ne soit pas encore connu, on pense que le médicament se lie aux mêmes récepteurs que l'adénosine dans le cerveau. Le modafinil fait également disparaître ses effets plus rapidement que certains autres médicaments disponibles sur le marché. Le modafinil est un médicament favorisant l'éveil qui a été développé dans les années 1970 comme traitement médical de la narcolepsie sévère. Le modafinil a également été utilisé pour augmenter la tolérance à la caféine et réveiller les individus à tolérance limitée. Le modafinil fait partie de la «grande famille» des agents favorisant l'éveil à action directe, qui comprend des médicaments tels que la caféine et l'amphétamine. Le modafinil est également conçu pour aider certaines personnes à mieux dormir la nuit. Le modafinil est un dérivé de la benzazépine et n'est pas structurellement lié à d'autres stimulants tels que l'amphétamine ou la méthamphétamine.

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#9
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