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Le modafinil est le N-Г©thyl-N-desmГ©thyl-modafinil, qui est la base libre du modafinil lui-mГЄme. Plusieurs Г©tudes humaines et animales suggГЁrent que le modafinil et l'armodafinil amГ©liorent la fonction cognitive chez les personnes non privГ©es de sommeil. Le modafinil n'est pas recommandГ© aux personnes souffrant d'affections pouvant ГЄtre causГ©es par une poussГ©e d'Г©nergie, notamment celles prГ©sentant une pression artГ©rielle instable, des arythmies, une maladie cardiaque, une mauvaise circulation ou une sensibilitГ© Г la cafГ©ine. Le modafinil est le nom de marque du mГ©dicament m-chlorophГ©nylpipГ©razine. Il a Г©tГ© rapportГ© qu'il amГ©liore l'Г©veil et la concentration chez les patients narcoleptiques, rГ©duit les sensations de fatigue et augmente la capacitГ© d'attention chez les patients souffrant d'apnГ©e du sommeil. Au-delГ de son utilisation principale pour le traitement de la somnolence due Г la narcolepsie, le modafinil a Г©tГ© Г©tudiГ© comme un traitement pour les personnes qui travaillent par quarts et les travailleurs postГ©s souffrant de troubles du sommeil liГ©s au travail par quarts, et comme traitement pour ceux qui souffrent d'apnГ©e obstructive du sommeil. Les quantitГ©s quotidiennes prises peuvent devoir ГЄtre augmentГ©es. Les effets secondaires rares et graves comprennent des rГ©actions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antГ©cГ©dents de psychose. Les effets secondaires du modafinil comprennent des nausГ©es, des maux de tГЄte, de l'anxiГ©tГ© et d'autres effets sur le SNC qui peuvent diminuer lors d'une utilisation prolongГ©e. Il est prescrit pour le traitement de la narcolepsie, du travail postГ©, de la somnolence excessive associГ©e Г l'apnГ©e obstructive du sommeil, de l'inertie du sommeil, ainsi que pour l'utilisation du modafinil chez les enfants souffrant de narcolepsie. Le mГ©dicament modafinil modifie les neurotransmetteurs centraux; il amГ©liore Г©galement le fonctionnement normal des neurotransmetteurs. L'arbre Swietenia pousse nativement au Malawi et au Mozambique. La Food and Drug Administration a approuvГ© le modafinil pour le traitement des troubles du travail postГ© aux Г‰tats-Unis. Il est disponible sous forme de comprimГ© contenant 100 mg de mГ©dicament actif et a Г©tГ© approuvГ© par la Food and Drug Administration pour le traitement de la narcolepsie, y compris chez les populations pГ©diatriques et adolescentes. acheter modafinil france Les effets secondaires les plus courants comprennent des difficultГ©s Г dormir et une sensation de fatigue et de tension. Cela peut ГЄtre particuliГЁrement important pour ceux qui utilisent ce mГ©dicament rГ©guliГЁrement. Les fabricants de mГ©dicaments sur ordonnance peuvent ne pas inclure le coГ»t des services ou des produits mГ©dicaux dans le prix indiquГ©. Il a Г©tГ© approuvГ© pour la commercialisation en France en 1994 et par la Food and Drug Administration (FDA) des Г‰tats-Unis en 1998. Dans le SNC, cela n'affectera probablement que les neurones qui ont Г©tГ© prГ©cГ©demment activГ©s par l'acГ©tylcholine. Le modafinil ne semble pas se lier au rГ©cepteur de l'acide Оі-aminobutyrique (GABA). Les formes en vente libre sont prises jusqu'Г quatre fois par jour, une dose initiale Г©tant prise le matin et des doses supplГ©mentaires Г intervalles rГ©guliers tout au long de la journГ©e. Des Г©tudes ont montrГ© que le modafinil gГ©nГ©rique est au moins aussi efficace que la version de marque pour l'usage auquel il est destinГ©. Le modafinil est un inhibiteur trГЁs puissant de la monoamine oxydase (MAO). Cela conduit Г son tour Г une meilleure activitГ© des ondes cГ©rГ©brales dans la zone du cortex frontal du cerveau. Aucune Г©tude n'a Г©tГ© faite pour prouver que l'amГ©lioration cognitive se produit par ce mГ©canisme.
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