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06-24-2023, 03:59 AM
(This post was last modified: 06-24-2023, 03:59 AM by Le Modafinil .)
Le mГ©canisme d'action exact du modafinil n'est pas clair. Les personnes qui en prennent ont tendance Г Г©prouver un sentiment initial de В« descente В». Le modafinil est un solide blanc Г lГ©gГЁrement jaune, sous forme cristalline et amorphe. On ne sait pas si le modafinil est efficace pour les personnes atteintes de narcolepsie. Il est disponible en tant que mГ©dicament gГ©nГ©rique. C'est un inhibiteur non sГ©lectif de la recapture de la norГ©pinГ©phrine, un inhibiteur de la recapture de la sГ©rotonine Г 5HT2A et un antagoniste muscarinique faible. Il est disponible en formulations orale et nasale. Les effets du modafinil sont similaires Г ceux de l'amphГ©tamine ou de la cocaГЇne, mais la plupart des gens ne ressentent aucun de ses effets secondaires, tels que l'anxiГ©tГ©, l'agitation ou l'agitation. Le traitement peut durer toute la vie et des augmentations de dosage peuvent ГЄtre nГ©cessaires pour prГ©venir la somnolence. Bien que le mГ©canisme d'action ne soit pas bien compris, on pense que le modafinil est un modulateur des rГ©cepteurs de l'adГ©nosine. Il s'agissait de traiter les troubles du sommeil sur le lieu de travail, car on croyait que les personnes souffrant d'insomnie seraient moins capables de maintenir leur attention au travail. ApprouvГ© par la Food and Drug Administration en 1998, le modafinil est utilisГ© pour traiter certains cas de somnolence excessive. La grossesse n'est pas recommandГ©e pendant le traitement par modafinil.
modafinil europe La narcolepsie est un trouble du sommeil impliquant l'incapacitГ© du corps Г contrГґler le dГ©but et le rythme du sommeil. La toxicitГ© est un problГЁme beaucoup plus courant avec les amphГ©tamines qu'avec le modafinil. Des doses de modafinil relativement faibles peuvent ne pas produire la mГЄme quantitГ© d'Г©veil ou prГ©venir la somnolence qui est gГ©nГ©ralement causГ©e par la privation de sommeil. Le modafinil, ou 2-[(diphГ©nylmГ©thyl)sulfinyl]acГ©tamide, est un stimulant. Le nom chimique et la structure indiquent que Modafinil est un stimulant. Il a Г©galement Г©tГ© dГ©veloppГ© dans les laboratoires de la SNCF Г Collioures, en France, et est maintenant fabriquГ© par Alkermes Inc. Le modafinil est utilisГ© pour traiter l'Г©veil chez les adultes qui manquent de sommeil ou qui souffrent de somnolence diurne excessive (EDS), comme chez les travailleurs postГ©s et les personnes qui travaillent de nuit. Des doses supГ©rieures Г 400 mg/jour peuvent entraГ®ner des troubles psychomoteurs importants. L'une des caractГ©ristiques uniques du modafinil est qu'aprГЁs environ sept heures suivant son administration, l'activitГ© enzymatique du CYP1A2 diminue Г environ 50 % ou moins de sa valeur maximale. Le modafinil a Г©tГ© Г©tudiГ© pour son efficacitГ© en tant que stimulant cognitif chez les personnes en bonne santГ© et les personnes handicapГ©es. Le modafinil est utilisГ© comme traitement de la somnolence liГ©e au travail postГ©.
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Le modafinil appartient Г la classe des mГ©dicaments appelГ©s agents favorisant l'Г©veil, qui stimulent le systГЁme nerveux, supprimant ainsi le sommeil. Si vous ГЄtes dans une situation oГ№ vous devez rester vigilant, par exemple lorsque vous conduisez, le modafinil est plus efficace le soir ou la nuit, lorsque vous ГЄtes le plus fatiguГ©. Le modafinil est absorbГ© rapidement et de maniГЁre fiable et ne provoque gГ©nГ©ralement pas de somnolence importante, car il s'agit d'un stimulant du SNC avec une action stimulante sur les voies dopaminergiques du cerveau. Il y a eu des utilisations hors AMM du modafinil dans de nombreuses conditions, y compris la dГ©pression, le TDAH, la sclГ©rose en plaques et le SSPT. Chaque comprimГ© contient 100 mg de modafinil et 200 mg de cafГ©ine. Cela peut varier selon la personne et dГ©pend de la dose. Le modafinil se prend par voie orale, souvent avec une boisson Г©nergisante ou du cafГ©. Des palpitations lГ©gГЁres, des Г©tourdissements, des maux de tГЄte et une lГ©thargie peuvent survenir. Son action exacte et son mГ©canisme d'action ne sont pas entiГЁrement connus. Il amГ©liore l'Г©veil du corps et aide Г amГ©liorer la fatigue et votre capacitГ© Г fonctionner.
modafinil europe MesurГ©e par colorimГ©trie, la teneur en modafinil varie de 98,2% Г 107,2% avec une seule prise. Il stimule Г©galement la libГ©ration de dopamine et augmente son action. L'acГ©tylcholine est un neurotransmetteur inhibiteur, qui agit de maniГЁre prГ©synaptique, il stimule la libГ©ration d'autres neurotransmetteurs. Le modafinil agit Г©galement sur le systГЁme sГ©rotoninergique ; une Г©tude a rГ©vГ©lГ© que les actions du modafinil incluent l'inhibition des transporteurs de la sГ©rotonine. Il est excrГ©tГ© sous forme inchangГ©e dans les urines. Un syndrome sГ©rotoninergique (c'est-Г -dire une agitation mentale et physique) peut survenir chez les personnes prenant du modafinil avec des inhibiteurs de la monoamine oxydase (IMAO). Les effets du modafinil durent jusqu'Г huit heures aprГЁs la prise d'une dose. La dose quotidienne maximale est de 1200 milligrammes (mg). Le modafinil peut Г©galement ГЄtre utilisГ© pour traiter les troubles du sommeil liГ©s au travail postГ©, oГ№ une personne dort Г son heure normale, mais maintient sa vigilance pour Г©viter de s'endormir sur son lieu de travail. Certains patients qui l'avaient utilisГ© pendant plusieurs mois, y compris dans des essais cliniques, ont signalГ© des effets secondaires tels que l'insomnie, l'agitation, l'anxiГ©tГ© et la nervositГ©. Il Г©tait Г l'origine utilisГ© pour traiter la somnolence excessive chez les patients atteints de narcolepsie, un trouble du sommeil. Le modafinil peut ГЄtre une alternative plus puissante et plus sГ»re aux mГ©dicaments tels que l'amphГ©tamine et la dexamphГ©tamine. Il est Г©galement associГ© au Ritalin ou Г l'Adderall dans certaines formes de combinaisons modafinil/Ritalin.
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