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Les effets secondaires courants comprennent les nausées, les troubles du sommeil et les maux de tête. Mais il est connu pour fonctionner comme un stimulant pour améliorer la conscience et l'énergie, et est parfois utilisé pour traiter le TDAH et l'incapacité à se concentrer causée par une grave privation de sommeil. Une fois que le médicament a été découvert, il a rapidement été retiré de l'utilisation clinique car il provoquait une rigidité sévère de la mâchoire, y compris l'érosion permanente de l'os. L'effet net est d'augmenter le niveau de vigilance, ce qui peut entraîner une augmentation de l'état de veille. Provigil a été développé par la société pharmaceutique française, Groupe Lafon. Il est utilisé pour lutter contre la fatigue après un quart de travail ou après une longue période de privation de sommeil. Bien qu'il ne soit généralement pas dangereux à des doses faibles à modérées, le modafinil est abusé dans certaines circonstances, comme pendant la journée, pour améliorer l'éveil, augmenter la concentration et la durée de concentration et diminuer l'anxiété. Il n'est pas clair si le modafinil présente des avantages significatifs en termes de cognition et de mémoire. Aux États-Unis, le prix de gros du modafinil était d'environ 5,0 millions de dollars en 2017. Le modafinil est un antagoniste de l'adénosine qui agit en augmentant l'adénosine extracellulaire, activant ainsi les récepteurs inhibiteurs de l'adénosine A1. Le modafinil est mieux absorbé lorsqu'il est pris avec de la nourriture, tôt le matin et avant le coucher.
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