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Le modafinil s'est avéré plus efficace que le piracétam pour améliorer les performances psychomotrices. On pense que le médicament améliore l'éveil du système nerveux central et a été utilisé avec succès pour le traitement de la somnolence excessive chez les patients narcoleptiques. Les souris recevant du modafinil ont connu moins d'épisodes de sommeil au total et des intervalles de repos plus longs entre les épisodes de sommeil. Les effets secondaires graves rares peuvent inclure des réactions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antécédents de psychose. Le modafinil est connu pour interférer avec la capacité du corps à métaboliser l'alcool, ce qui signifie que les personnes qui boivent avec du modafinil peuvent ressentir une augmentation de l'intoxication. D'autres exemples sont le besoin d'oxygène et de concentration. Le Modafinil a été développé pour la première fois dans les années 1970 par les Laboratoires Jouvet et Lafon. Le modafinil a été développé à l'origine dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon, et est commercialisé sous le nom de Provigil. En 1998, il a été recommandé pour une utilisation dans la narcolepsie. La somnolence, qui résulte du sevrage d'un stimulant chronique, est plus sévère chez les personnes atteintes de narcolepsie. La posologie prescrite varie de 100 à 200 mg, à prendre une ou deux fois par jour avant le début du sommeil. Le modafinil est parfois utilisé par des personnes en bonne santé pour améliorer les performances et la cognition, et en raison de ses effets stimulants. modiodal drogue Le modafinil servirait d'agoniste des récepteurs D1/D2, agissant éventuellement en se liant au transporteur de la dopamine (DAT) pour augmenter la dopamine dans le cortex frontal. Initialement, Modafinil a été approuvé uniquement pour le traitement de l'apnée du sommeil. Le modafinil peut également prolonger l'intervalle QTc chez les personnes ayant des intervalles QTc prolongés. Ces doses sont équivalentes à 100 mg d'amphétamine, 200 mg de méthylphénidate et 400 mg de méthylphénidate. Le modafinil est utilisé pour traiter la somnolence causée par la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Le taux de diffusion de la dopamine dans le noyau accumbens du cerveau est augmenté par le modafinil. Si vous ressentez des effets secondaires excessifs, vous pouvez prendre le médicament à une dose plus faible. Le liquide, qui peut être exprimé dans un autre liquide injectable, est contenu dans une seringue et nécessite l'insertion d'un dispositif sans aiguille dans la bouche de l'utilisateur, entre la joue et la gencive. Le modafinil est un stimulant du système nerveux central qui agit en arrêtant le cycle du sommeil et en permettant au corps de rester éveillé pendant une période prolongée. Le modafinil doit être pris au moins quatre heures avant de dormir, et une nuit complète de sommeil est recommandée.
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