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[Le Modafinil]

Le modafinil est un stimulant du SNC qui produit l'Г©veil. Certains ont suggГ©rГ© que ces mГ©dicaments pourraient ГЄtre utiles pour maintenir l'Г©veil au travail ou Г  l'Г©cole. En tant que stimulant du SNC, le modafinil aide Г  amГ©liorer la vigilance et la concentration, et est souvent utilisГ© par les Г©tudiants pendant leur journГ©e de travail pour rester Г©veillГ© et mieux performer. Disponible en comprimГ©s de 30 mg et 200 mg, le modafinil est disponible en plusieurs formulations et dosages, et se prend par voie orale. Il a Г©galement un effet stimulant sur les vaisseaux sanguins, augmentant le flux sanguin et l'oxygГ©nation. Le modafinil a Г©tГ© approuvГ© pour une utilisation dans le traitement de la narcolepsie en France en 1994 et aux Г‰tats-Unis en 1998, sur la base d'un essai de 39 adultes atteints de narcolepsie traitГ©s avec le mГ©dicament pendant jusqu'Г  quatre ans. Il ne semble pas altГ©rer la sensibilitГ© des rГ©cepteurs ou provoquer une dГ©sensibilisation des rГ©cepteurs. La quantitГ© de mГ©dicament utilisГ©e peut devoir ГЄtre ajustГ©e chez les personnes souffrant de problГЁmes rГ©naux ou hГ©patiques. Il peut ГЄtre pris en association avec d'autres mГ©dicaments pour traiter d'autres affections. Le modafinil est sur le marchГ© depuis 1994. modafinil belgique Il peut Г©galement interagir avec d'autres mГ©dicaments utilisГ©s pour traiter les troubles du sommeil. Cette connaissance a Г©tГ© rГ©cemment rГ©visГ©e aprГЁs l'approbation de Modafinil pour une utilisation dans la narcolepsie ; la FDA a constatГ© que, comme dans le cas du stimulant mГ©thylphГ©nidate, le Modafinil stimule Г©galement le transporteur de la dopamine. Le modafinil est Г©galement un inhibiteur de la recapture de la sГ©rotonine-norГ©pinГ©phrine. La structure de ce produit se prГ©sente sous la forme d'une Г©mulsion, qui est une version plus concentrГ©e d'un systГЁme transdermique, mais dans un format plus adaptГ© Г  une application sur la peau. Le modafinil est un analogue de l'acide aminГ© naturel L-tryptophane. La formulation de modafinil approuvГ©e par la FDA est le modafinil (Alertec, Provigil, Janssen R&D), qui se compose de granulГ©s de modafinil avec du lactose. Le modafinil est vendu comme complГ©ment alimentaire ou comme mГ©dicament pour l'amГ©lioration cognitive. Ces effets sont complexes et diffГЁrent d'une personne Г  l'autre. Le modafinil est commercialisГ© sous forme de comprimГ© Г  prendre par voie orale, de comprimГ©s pour suspension buvable et de mГ©dicament sublingual Г  utiliser avec Suboxone. Dans le traitement de la narcolepsie avec cataplexie, le modafinil est utilisГ© Г  une dose de 100 Г  400 mg par jour. Une dose complГЁte de modafinil consiste en 200 mg, 400 mg ou 600 mg une fois par jour. La formule molГ©culaire est C22H20N4O3 . La FDA a approuvГ© Provigil en 1998 pour la narcolepsie. Les stimulants du SNC peuvent augmenter la vigilance et l'attention, ou peuvent augmenter l'humeur et l'Г©nergie. Les effets sont utilisГ©s pour augmenter l'Г©veil et prГ©venir ou attГ©nuer les effets de la somnolence.

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Les personnes qui prennent du Modafinil pendant une longue pГ©riode, en conduisant ou dans le cas des personnes atteintes de narcolepsie, il peut ГЄtre risquГ© d'ГЄtre conscient de leur environnement car leur esprit est complГЁtement engagГ© dans le travail, les Г©tudes ou mГЄme le jeu. Lorsqu'il est utilisГ© pour les travailleurs postГ©s et comme traitement pour les travailleurs postГ©s, les effets secondaires les plus frГ©quemment rapportГ©s sont des Г©tourdissements et d'autres effets sur le SNC. La recherche montre qu'il a Г©tГ© dГ©couvert et utilisГ© pour la premiГЁre fois comme mГ©dicament pour favoriser la vigilance chez les personnes atteintes de narcolepsie, et a depuis Г©tГ© utilisГ© comme mГ©dicament d'ordonnance amГ©liorant l'Г©veil pour le traitement des troubles du sommeil liГ©s au travail postГ© et de l'apnГ©e obstructive du sommeil. Seize ont eu ces problГЁmes en prenant du Modafinil, trois les ont eu aprГЁs l'avoir pris et six ont eu des problГЁmes en prenant un mГ©dicament diffГ©rent. Il augmente l'Г©veil en augmentant l'activitГ© de la dopamine favorisant l'Г©veil sans supprimer l'activitГ© de la sГ©rotonine favorisant le sommeil. En 2016, Nathan J. Le modafinil est un analogue synthГ©tique non amphГ©tamine des amines adrГ©nergiques. Dans certains cas, le mГ©dicament peut amГ©liorer l'humeur. C'est l'ingrГ©dient actif d'Edluaril. Une capsule contenant du modafinil est disponible, mais n'est pas une formulation typique utilisГ©e dans les Г©tudes sur son efficacitГ©. Il s'agit d'un bloqueur putatif de la recapture de la dopamine et possГЁde des rГ©cepteurs inconnus qui peuvent ГЄtre liГ©s au mГ©canisme d'action. Les personnes qui prennent ce mГ©dicament doivent consulter leur mГ©decin avant la grossesse. Le modafinil semble agir principalement sur les zones du cerveau impliquГ©es dans l'Г©veil et l'activitГ© motrice. Cette heure et ce jour de prise, ainsi que la dose, varieront d'un individu Г  l'autre. modafinil belgique Il a Г©tГ© utilisГ© pour traiter un certain nombre de troubles psychiatriques tels que la dГ©pression, le trouble bipolaire et la schizophrГ©nie. La dose recommandГ©e se situe entre 100 et 200 milligrammes, Г  prendre avant le coucher. Il est associГ© Г  une amГ©lioration de la somnolence et Г  une rГ©duction de la latence d'endormissement, attГ©nuant ainsi les effets nГ©gatifs de la perte de sommeil. Il a Г©galement Г©tГ© approuvГ© pour les troubles du sommeil liГ©s au travail postГ© et pour l'apnГ©e obstructive du sommeil (OSA). Dans les Г©tudes humaines, il a Г©tГ© dГ©montrГ© que le modafinil amГ©liore l'attention, la concentration et la mГ©moire. Les plus grands essais d'efficacitГ© ont des doses comprises entre 200 mg et 400 mg. Med Hypoth Sci. La somnolence diurne excessive associГ©e Г  la narcolepsie est un problГЁme mГ©dical courant, gГ©nГ©ralement traitГ© avec du modafinil. Bien que le modafinil ne se substitue pas Г  un traitement plus complet des troubles du sommeil, ou en tant qu'aide au sommeil Г  part entiГЁre, il a Г©tГ© largement Г©tudiГ© chez les personnes souffrant de troubles du sommeil, telles que celles souffrant de somnolence excessive due Г  la narcolepsie. п»їLe modafinil est un analogue synthГ©tique du mГ©thylphГ©nidate. Le modafinil est mГ©tabolisГ© par le CYP2C19 et le CYP3A4. De rares rГ©actions dermatologiques graves peuvent survenir chez les personnes prГ©sentant des prГ©dispositions gГ©nГ©tiques et plus frГ©quemment chez les patients pГ©diatriques.

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