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06-24-2023, 08:03 PM
(This post was last modified: 06-24-2023, 08:03 PM by Le Modafinil.)
Des Г©tudes suggГЁrent que l'utilisation de modafinil pendant les heures d'Г©veil d'une personne assouplit son cycle veille-sommeil. Les effets secondaires du modafinil peuvent entraГ®ner de la somnolence et des nausГ©es, semblables aux amphГ©tamines. Il semble Г©galement inhiber la libГ©ration d'acГ©tylcholine, un neurotransmetteur inhibiteur. Le modafinil est un antagoniste sГ©lectif de l'histamine H1. Le modafinil a Г©tГ© comparГ© Г l'amphГ©tamine dans quelques petits essais cliniques. Il Г©tait basГ© sur une dГ©couverte accidentelle de Kaplan et alkylait une famille chimique appelГ©e 2-benzyl-1,3-thiazolidine-4-ones, entraГ®nant la dГ©couverte de 2-[(diphГ©nylmГ©thyl)-sulfinyl]-1,3-thiazolidine-4-one. Le modafinil ne semble pas affecter le rythme circadien ou la production de mГ©latonine chez les individus en bonne santГ©, et il a une demi-vie d'environ deux heures. Il est dГ©rivГ© d'un groupe de mГ©dicaments appelГ©s stimulants. Les effets secondaires du modafinil ne sont pas bien connus. Il n'est pas recommandГ© chez les personnes souffrant d'arythmie, d'hypertension artГ©rielle, d'hypertrophie ventriculaire gauche importante ou de dГ©pression. Le modafinil est un mГ©lange de deux substances chimiques : le citrate de modafinil, un analogue du neurotransmetteur dopamine, et son mГ©tabolite actif, le N-desmГ©thyl modafinil. Au Royaume-Uni, le prix de gros moyen de Modalert est de 0,47 ВЈ et le prix de dГ©tail moyen est de 0,68 ВЈ. Ces effets ont persistГ© pendant au moins deux heures aprГЁs l'administration du modafinil. acheter modiodal Le modafinil n'a pas Г©tГ© approuvГ© par la Food and Drug Administration (FDA) des Г‰tats-Unis pour l'amГ©lioration cognitive chez les personnes en bonne santГ©. Selon une enquГЄte de 2014, 3,4 millions d'AmГ©ricains ont utilisГ© le modafinil pour les troubles du sommeil, dont environ 1,1 million ont pris le mГ©dicament pour l'indication de la narcolepsie. Il est gГ©nГ©ralement pris trois fois par jour. En 2000, un La science Une Г©tude a montrГ© que le modafinil n'Г©tait associГ© Г aucune amГ©lioration significative du temps de rГ©action, de la mГ©moire ou de l'attention, ni mГЄme Г une attention soutenue, par rapport au placebo. On ne sait pas si l'utilisation pendant la grossesse est sans danger. Le modafinil est un mГ©dicament bien tolГ©rГ©, Г prendre une fois par jour, utilisГ© pour traiter les symptГґmes de la narcolepsie, des troubles du sommeil liГ©s au travail postГ© et de la somnolence chronique due Г l'apnГ©e obstructive du sommeil. Le modafinil se dissout rapidement dans la bouche et pГ©nГЁtre dans la circulation sanguine. Il peut augmenter les effets des sГ©datifs et d'autres dГ©presseurs du SNC. Le modafinil Г©tait Г l'origine vendu sous le nom de marque Provigil. La recherche indique que Modafinil agit en augmentant l'action de la dopamine, un neurotransmetteur. Le modafinil est indiquГ© dans le traitement des troubles du sommeil liГ©s au travail postГ© lorsqu'il est associГ© Г une qualitГ© ou une quantitГ© de sommeil insuffisante. Le modafinil affecte Г©galement directement la neurochimie du cerveau. Sa demi-vie est gГ©nГ©ralement plus faible chez les personnes ГўgГ©es.
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Cela a été vendu comme le médicament Provigil. Ces stimulants augmentent le flux sanguin dans les zones du cerveau impliquées dans l'éveil. Les deux énantiomères sont des isomères optiques et deux diastéréoisomères sont généralement produits. Il est également utilisé pour les personnes souffrant de migraines et utilisé comme coupe-faim. Des doses plus importantes de modafinil peuvent être utilisées si nécessaire. En 2011, le New England Journal of Medicine a émis un avertissement selon lequel le Modafinil peut provoquer des effets indésirables graves chez certaines personnes souffrant de troubles psychiatriques préexistants. Les traitements de marque les plus chers sont généralement pris une fois par jour le matin. Les effets secondaires rares et graves peuvent inclure des réactions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antécédents de psychose. Le nom de marque d'origine est Provigil, son nom commercial aux États-Unis. Le modafinil a été revendiqué pour augmenter l'éveil, diminuer la fatigue et prolonger le temps de réaction. acheter modiodal Le modafinil n'est pas approuvé pour une utilisation chez les personnes ayant une condition médicale cliniquement significative ou celles qui prennent d'autres médicaments actifs sur le SNC. Les personnes qui souffrent de somnolence et de faibles niveaux de vigilance au milieu de la journée, en particulier lorsqu'elles ressentent une augmentation de la fatigue après le réveil, peuvent bénéficier du modafinil. Par conséquent, le modafinil doit être évité par les personnes dont l'intervalle QTc est prolongé, y compris les personnes ayant des antécédents d'hypokaliémie ou d'hypomagnésémie. Dans une expérience en laboratoire, le modafinil a augmenté l'éveil à court terme en améliorant ou en maintenant l'éveil, mais n'a eu aucun effet sur le cycle veille-sommeil. Il n'est pas recommandé chez les personnes souffrant d'arythmie, d'hypertension artérielle importante ou d'hypertrophie ventriculaire gauche. Actuellement, le modafinil est le plus couramment utilisé pour les troubles du sommeil liés au travail posté. Une étude a révélé que les patients prenant du modafinil affichaient une décroissance plus lente de l'activité cérébrale, mesurée par tomographie par émission de positrons, par rapport aux témoins sains. Le modafinil a été approuvé en 1998 pour le traitement de la somnolence diurne excessive chez les personnes souffrant d'apnée obstructive du sommeil et est commercialisé sous le nom de marque Provigil. Il n'y a pas d'interactions connues avec d'autres médicaments. Les personnes à risque de développer une cardiopathie valvulaire et/ou des prothèses valvulaires cardiaques peuvent être exposées à un risque accru d'événements prothrombotiques. Le modafinil semble agir en agissant sur la dopamine et en modulant les zones du cerveau impliquées dans le cycle du sommeil. De cette façon, ils affectent les zones cérébrales responsables de la somnolence et aident à l'éveil. La dose quotidienne en général est de 200 à 400 mg et doit être prise avec de la nourriture.
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