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[Le Modafinil]

On pense que le principal mode d'action du modafinil est via une liaison spécifique au récepteur nicotinique α4β2-acétylcholine, bien qu'il puisse également agir sur les récepteurs α2β4- et α3β2-acétylcholine. Un stimulant est défini comme un médicament qui augmente la vigilance, la concentration et/ou la production d'autres humeurs. Avant de prendre Modafinil, les femmes doivent discuter de la possibilité d'une grossesse avec leur médecin. Ces transporteurs de dopamine inhibent la recapture de la dopamine, un neurotransmetteur clé du cerveau. Le modafinil a été utilisé hors AMM pour le traitement de la fatigue chez les survivants du cancer, une population gravement privée de sommeil. La dose optimale est de 200 mg trois fois par jour ou de 200 mg une fois par jour. Il est conçu pour imiter ou améliorer l'éveil et il est vendu sous des noms commerciaux tels que Alertec, Aptensio, Armodafinil, Modafinil, Nuvigil et Ritalin-M, et le nom générique Modafinil. Le médicament est disponible sous forme de comprimés de 100 mg et 200 mg. Pour traiter la somnolence due à la narcolepsie et aux troubles du sommeil liés au travail posté, un comprimé de 100 mg (ou 50 mg par voie orale pour les travailleurs postés) est recommandé. Le principal ingrédient pharmaceutique actif du modafinil est le N-acétyl-d-aspartyl-d-glutamate (NAAG), bien que la concentration exacte de cet ingrédient ne soit pas connue. Son nom de marque commun aux États-Unis est Provigil et au Royaume-Uni, Modafinil. Les personnes ayant des problèmes cardiaques, des antécédents de psychose ou les personnes prenant certains médicaments doivent savoir que ces effets secondaires sont possibles avant utilisation. Comme d'autres stimulants du système nerveux central, le modafinil est utilisé pour traiter les états de somnolence diurne excessive (EDS). En effet, il est indétectable dans le sang s'il est pris à doses thérapeutiques mais détectable si la dose efficace a été dépassée. modiodal sans ordonnance Le modafinil a été introduit en France en 1994 comme somnifère diurne, puis utilisé aux États-Unis en 1997 pour traiter la narcolepsie (Lafon C, Modafinil: a double blind study on schizophrenic and narcoleptic patients. Le comprimé contient également les ingrédients inertes lactose, cellulose microcristalline et phosphate dicalcique, lactose, magnésie et amidon de maïs, et est sécable pour faciliter l'administration. Un autre essai clinique portant sur 12 patients atteints du trouble du sommeil connu sous le nom d'hypersomnie a révélé que plus de 10 mois de traitement avec 400 mg de modafinil pendant 90 jours étaient sans danger, mais que l'effet sur la somnolence était inférieur à celui observé avec l'amphétamine, un médicament stimulant. Il est bien toléré, avec des effets secondaires possibles, notamment des maux de tête, des troubles du sommeil et des nausées. Il a été développé à l'origine par des chercheurs de l'Université de Bordeaux. La proportion de patients affectés par le modafinil par rapport au placebo était importante dans tous les essais (intervalle de taille d'effet = -0,78 à -1,2, selon le critère d'évaluation), et la durée des essais était d'une semaine ou plus. Modafinil, modafinil-alfa ou modafinil-beta sont des noms de marque pour le modafinil de Cephalon. Le modafinil se prend par voie orale. Vous devez noter que la batterie CogState a été utilisée dans l'essai mentionné ci-dessus et que les études incluses dans cette revue n'ont pas été spécifiquement conçues pour détecter les effets sur les performances cognitives. Il a été démontré dans des études animales et humaines qu'il se lie et active des sites du cerveau qui sont impliqués dans la production et l'élimination de l'adénosine, un neurotransmetteur induisant le sommeil, et augmente les niveaux d'acétylcholine dans le SNC. En règle générale, la moitié de la dose recommandée est prise 2 heures avant d'aller au lit.

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L'American Academy of Sleep Medicine a notГ© que le modafinil peut ГЄtre efficace pour le traitement de l'insomnie, mais ne peut ГЄtre recommandГ© comme agent de В« substitut В» ou de deuxiГЁme intention pour les insomniaques que si les agents de premiГЁre intention tels que les benzodiazГ©pines, les antidГ©presseurs ou les stimulants ne sont pas efficaces. La version Г  libГ©ration prolongГ©e, Armodafinil, est approuvГ©e pour le traitement des troubles du sommeil liГ©s au travail postГ©. Cela augmente la quantitГ© de sГ©rotonine disponible pour le cerveau. Deux prГ©parations contiennent 600 mg, chaque comprimГ© contenant 150 mg de modafinil et les 450 mg restants d'ingrГ©dients inertes. La FDA a approuvГ© son utilisation dans le Г‰tats-Unis en 1998. Des Г©tudes montrent que le modafinil amГ©liore le temps pendant lequel une personne peut rester Г©veillГ©e. Bien que le modafinil soit gГ©nГ©ralement pris le matin pour son effet stimulant, certains pensent que le prendre le matin ne produit pas le mГЄme effet. Il a ensuite Г©tГ© commercialisГ© sous le nom de Concerta au Canada et a d'abord Г©tГ© vendu sous le nom de marque Nuvigil dans le reste du monde. Il a Г©tГ© utilisГ© Г  des fins rГ©crГ©atives comme amГ©lioration cognitive. Il a Г©tГ© utilisГ© hors AMM chez des patients sans narcolepsie qui ne rГ©pondent pas aux autres mГ©dicaments. Il a Г©tГ© dГ©montrГ© que le modafinil modifie les niveaux de neurotransmetteurs, notamment la noradrГ©naline, la sГ©rotonine et la dopamine. Modisette et Richard E. modiodal sans ordonnance Modafinil a Г©tГ© trouvГ© pour stimuler la synthГЁse de Dopamine. Le modafinil est un stimulant du systГЁme nerveux central mГ©dicament pour la narcolepsie. En rГЁgle gГ©nГ©rale, une dose initiale de 100 Г  200 mg par jour est considГ©rГ©e comme sГ»re. L'utilisation de doses quotidiennes de 50 Г  100 mg rГ©duit la somnolence et amГ©liore les performances au travail chez les patients atteints de narcolepsie. Il est recommandГ© de ne pas le prendre plus de quatre heures avant de conduire ou d'utiliser des machines. Il a Г©tГ© utilisГ© avec succГЁs dans le traitement de la somnolence excessive pendant le sevrage alcoolique, chez les personnes souffrant d'insomnie d'endormissement et chez les travailleurs postГ©s. Le modafinil est indiquГ© pour le traitement de la somnolence diurne excessive associГ©e Г  la narcolepsie. Des Г©tudes Г  long terme sur l'utilisation du modafinil pour l'amГ©lioration cognitive chez les individus en bonne santГ© font encore dГ©faut, mais plusieurs Г©tudes ouvertes font Г©tat d'effets positifs. Cela pourrait entraГ®ner une moindre protection contre les radicaux oxygГ©nГ©s. Trop de modafinil peut provoquer une variГ©tГ© d'effets secondaires, tels que devenir hyperactif, irritable et faire des cauchemars. L'arbre Swietenia pousse nativement au Malawi et au Mozambique. Cependant, Г  des doses plus Г©levГ©es, on pense qu'il agit indirectement comme un agoniste complet du rГ©cepteur de la dopamine D1 et seulement un antagoniste partiel du rГ©cepteur de la dopamine D2, entraГ®nant une stimulation plus significative et plus durable des rГ©cepteurs de la dopamine. Il a un profil pharmacologique unique, car c'est un antagoniste compГ©titif des rГ©cepteurs DA (rГ©cepteur D2/D2).

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