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#7
Le modafinil est un médicament stimulant. Cela devrait être fait avant de l'utiliser pendant plus de quelques jours, cependant, afin d'éviter tout problème. Le modafinil a une plus grande affinité pour le récepteur de la dopamine que le méthylphénidate. Le modafinil, qui se lie également aux récepteurs de l'adénosine A1, agit en bloquant ces récepteurs, ce qui entraîne une augmentation des niveaux d'AMPc dans le cerveau. Le modafinil est efficace dans le traitement de la somnolence due à la narcolepsie et aux troubles du sommeil liés au travail posté, mais peut ne pas fonctionner aussi bien pour les personnes souffrant d'apnée obstructive du sommeil. Le médicament agit en agissant comme un stimulant du système nerveux central. La dose peut être augmentée progressivement jusqu'à la dose cible. Semblable à l'alcool, le modafinil est également un puissant stimulant du SNC. Fabriqué par Glenmark, Modafinil est formulé sous forme de poudre blanc cassé à blanc ou de poudre cristalline cristalline, qui est disponible en deux dosages : 200 mg (Provigil) et 400 mg (Afinia). D'autres médicaments peuvent interagir avec le modafinil et réduire son efficacité. Le modafinil est un médicament d'ordonnance développé dans les années 1970 pour traiter la narcolepsie. modafinil europe Le modafinil est un dérivé synthétique d'un alcaloïde végétal, l'acétylhomocystéine. Le modafinil est généralement pris juste avant le coucher, mais peut être pris n'importe où dans la journée ou le soir, mais le plus souvent le matin. C'est ce qu'on appelle le cycle du sommeil. La substance est commercialisée comme médicament dans un certain nombre de pays, dont les États-Unis, le Royaume-Uni, le Japon, Israël, la Thaïlande, le Canada, la Finlande, la France, l'Allemagne, l'Espagne, l'Italie et bien d'autres. Le modafinil, www. Bien que sa chimie semble logique, le mécanisme d'action exact du modafinil n'est pas clair. Il est également prescrit comme modafinil, et comme Armodafinil ou Armodafinil-RA. Le modafinil est un isomère d et possède des effets stimulants sélectifs et indirects sur les voies dopaminergiques du cerveau. C'est un neurostimulant qui agit en augmentant la transmission noradrénergique et dopaminergique dans le cerveau, pour augmenter l'éveil et diminuer la somnolence. Le médicament a été inventé dans les années 1970 par le neuroscientifique français Michel Jouvet du Centre de recherche de La Rochelle et la société pharmaceutique française Laboratoires Lafon, et lancé en 1987.

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Il doit ГЄtre pris environ 60 minutes avant toute heure de sommeil prГ©vue. Il est peu probable que le modafinil ait un effet sur les systГЁmes hormonaux du corps. Le modafinil est disponible en trois dosages : 200 mg, 400 mg et 600 mg. Si vous avez du mal Г  dormir et qu'il n'y a pas de raison claire, consultez votre mГ©decin pour confirmer que ce mГ©dicament est sans danger pour vous. L'effet secondaire le plus courant du modafinil est la sГ©dation diurne, qui est une propriГ©tГ© dose-dГ©pendante. Dans les essais cliniques, les personnes prenant du modafinil dormaient en moyenne 50 Г  58 minutes de moins par nuit que les personnes prenant un placebo. On pense que le mГ©dicament provoque une libГ©ration de dopamine et de noradrГ©naline, ce qui entraГ®ne une lГ©gГЁre stimulation du systГЁme nerveux central. Le modafinil est un analogue de l'amphГ©tamine. Ces sous-types alpha sont impliquГ©s dans la rГ©gulation du mГ©tabolisme de la dopamine et se trouvent Г  des concentrations Г©levГ©es dans certaines rГ©gions du cerveau. C'est la forme active du modafinil le plus couramment prescrit. Le modafinil inhibe l'enzyme butyrylcholinestГ©rase (BuChE), contrairement Г  l'exo-modafinil. Provigil a d'abord obtenu l'approbation rГ©glementaire aux Г‰tats-Unis pour le traitement des troubles du sommeil liГ©s au travail postГ© en janvier 1998, et pour le traitement de la somnolence excessive associГ©e Г  la narcolepsie en janvier 2000, et est prescrit en Europe depuis 1994. Le modafinil augmente les niveaux d'histamine dans le cerveau jusqu'Г  50 fois ceux trouvГ©s chez les personnes non traitГ©es. modafinil europe On estime que le modafinil a une demi-vie de 5 Г  6 heures. Il n'est pas clair si l'utilisation pendant la grossesse est sans danger. Le modafinil est un stimulant fabriquГ© Г  partir de la luzerne chimique. Les rГ©cepteurs de la dopamine comprennent D1 et D2, tous deux situГ©s dans les ganglions de la base. Le modafinil agit probablement en augmentant l'activitГ© dans plusieurs zones du cerveau, y compris l'hypothalamus et le noyau dorsomГ©dian de l'hypothalamus. Bien que la FDA ne supervise pas son utilisation, il a Г©tГ© prescrit pour une utilisation chez les personnes souffrant de narcolepsie de type В« prГ©dominant pendant le sommeil В» et chez les personnes qui effectuent un travail postГ© et se trouvent incapables de rester Г©veillГ©es pendant les heures de travail. Le modafinil est commercialisГ© pour une variГ©tГ© de conditions dans lesquelles une vigilance accrue serait utile. Il peut ГЄtre utilisГ© pour traiter les troubles du sommeil liГ©s au travail postГ© causГ©s par le type d'horaire de travail qui implique d'ГЄtre Г©veillГ© ou de fonctionner pendant de longues pГ©riodes pendant plusieurs nuits consГ©cutives, quel que soit le cycle circadien. L'efficacitГ© clinique du modafinil pour le traitement de la somnolence excessive causГ©e par le syndrome de fatigue chronique n'a pas Г©tГ© prouvГ©e. Le modafinil se prend sous forme de comprimГ© ou de spray nasal. Bien que tous les Modafinil ne fonctionnent pas de la mГЄme maniГЁre, tous augmentent l'Г©veil et la vigilance. Lorsque la dopamine est stimulГ©e de cette maniГЁre, elle provoque la libГ©ration de noradrГ©naline qui augmente la vigilance et l'Г©veil. Le modafinil se prГ©sente sous forme de gГ©lules de 100 Г  200 mg et est disponible en dosages de 50 Г  400 mg. Il agit pour augmenter la disponibilitГ© de la dopamine et de la noradrГ©naline dans le locus ceruleus et l'Г©quilibre noradrГ©nergique/cholinergique dans le cortex et l'hippocampe. Le modafinil est un agoniste partiel des transporteurs de la dopamine, de l'adГ©nosine et de la sГ©rotonine, mais possГЁde Г©galement une faible activitГ© dopaminergique et sГ©rotoninergique.

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