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#7
Lorsqu'il est pris tel que prescrit, il peut favoriser l'Г©veil et rГ©duire la fatigue. Il y a Г©galement eu des cas de modafinil augmentant potentiellement le risque de suicide. Dans de rares cas, les personnes peuvent dГ©velopper des hallucinations (par exemple, percevoir que des personnes ou des animaux se dГ©placent autour d'objets ou s'engagent dans des activitГ©s qui ne se produisent pas rГ©ellement). Le modafinil est disponible sous forme de comprimГ©s oraux Г  libГ©ration prolongГ©e et Г  libГ©ration immГ©diate. Le modafinil est utilisГ© pour rГ©duire les symptГґmes de la narcolepsie, un trouble du sommeil dans lequel l'individu subit des attaques soudaines et incontrГґlables de faiblesse musculaire causГ©es par des Г©pisodes de sommeil paradoxal (REM). Il В« agit probablement en agissant sur les systГЁmes de dopamine et d'acГ©tylcholine (ACh) В», selon le Canadian Medical Association Journal. Cela peut expliquer les effets dose-rГ©ponse observГ©s chez les personnes, plutГґt qu'une simple inversion d'un effet stimulant (par exemple, comme ce serait le cas pour un agent bloquant le DAT). Le modafinil a Г©tГ© utilisГ© en France jusqu'en 1994, date Г  laquelle il a Г©tГ© recommandГ© pour la narcolepsie, et a Г©tГ© approuvГ© aux Г‰tats-Unis en 1998. Cependant, il n'amГ©liore pas la continuitГ© du sommeil ni l'apnГ©e obstructive du sommeil. Il a Г©tГ© dГ©montrГ© que le modafinil a une affinitГ© plus forte pour le rГ©cepteur dopaminergique D1 que pour le rГ©cepteur D2, tandis que le mГ©thylphГ©nidate a une affinitГ© plus forte pour le rГ©cepteur D2 que pour le rГ©cepteur D1. Les donnГ©es concernant la vitesse Г  laquelle Modafinil atteint le cerveau sont limitГ©es, mais on pense que cela prend entre 1 et 3 heures. п»їLe principe actif du modafinil est le R-modafinil. Ces neurotransmetteurs agissent sur les rГ©cepteurs adrГ©nergiques, dopaminergiques et sГ©rotoninergiques. Le modafinil est un mГ©dicament d'ordonnance utilisГ© pour aider les gens Г  rester Г©veillГ©s et alertes. Cependant, le Modafinil a Г©tГ© approuvГ© avec une indication de somnolence associГ©e au travail postГ© et cela reste une rГ©fГ©rence commerciale pour la commercialisation du mГ©dicament. modiodal sans ordonnance Le modafinil est disponible sous forme de comprimГ©s, de bandes de film et de comprimГ©s Г  libГ©ration prolongГ©e. Il est approuvГ© par la Food and Drug Administration pour le traitement de la somnolence excessive associГ©e Г  la narcolepsie. Le modafinil empГЄche certains types de stimulants d'atteindre le cerveau. Bien que le modafinil soit gГ©nГ©ralement bien tolГ©rГ©, les effets indГ©sirables tels que les rГЄves vifs et l'augmentation du rythme cardiaque ne sont pas nГ©cessairement les effets secondaires d'un mГ©dicament qui aide Г  l'apnГ©e du sommeil. Les effets secondaires rares et graves comprennent des rГ©actions allergiques telles que l'anaphylaxie et le syndrome de Stevens-Johnson, ainsi que des hallucinations chez les personnes ayant des antГ©cГ©dents de psychose. Le modafinil est souvent utilisГ© pour le traitement des troubles du sommeil ou de la somnolence excessive dans les conditions liГ©es au sommeil. Le modafinil agit en interfГ©rant avec ces transporteurs, et donc le modafinil augmente le nombre de transporteurs de dopamine dans la synapse. La dose initiale recommandГ©e est de 100 mg trois fois par jour et la dose maximale est de 400 mg. La substance active est le modafinil, le N-Г©thyl-modafinil (4-Г©thoxy-Г©thyl-homospermine), un dГ©rivГ© indole. Le modafinil augmente la production de substances chimiques cГ©rГ©brales appelГ©es monoamines et dopamine. Ces rГ©sultats sont Г©tayГ©s par certains essais cliniques humains. Dans une Г©tude de 2014, les chercheurs ont dГ©couvert que l'effet du modafinil Г©tait moindre lorsque les gens Г©taient "encouragГ©s Г  apprendre Г  mieux dormir".

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Les symptômes du SWSD comprennent la somnolence diurne, les mauvaises performances au travail, les trous de mémoire, les accidents de la route et la somnolence diurne. Dans certains cas, des personnes sont décédées à cause d'une surdose de modafinil. Le modafinil est contre-indiqué chez les personnes ayant des antécédents d'hypersensibilité au modafinil et à ses constituants. Cela a conduit à la promotion du Modafinil comme stimulant cognitif par des individus en bonne santé pour stimuler l'énergie et la concentration. Il est important de noter que la National Sleep Foundation définit quatre catégories de somnolence : L'utilisation du modafinil est approuvée aux États-Unis par la Food and Drug Administration (FDA) des États-Unis pour traiter la narcolepsie, les troubles du sommeil liés au travail posté et l'apnée obstructive du sommeil. Son utilisation à des fins stimulantes ou d'amélioration cognitive n'est pas approuvée par la Food and Drug Administration (FDA) des États-Unis. Cela ne fait pas arrêter quelqu'un de respirer. Le modafinil augmente indirectement la libération de dopamine en augmentant la sécrétion des hormones hormone corticotrope (ACTH) et cortisol, qui à leur tour stimulent la synthèse et la sécrétion de dopamine. Pour la plupart, une seule dose de 200 mg est la bonne quantité, bien que certains pensent que cela fonctionne mieux si la dose est fractionnée. Le modafinil est disponible en dosages de 4 mg, 5 mg et 10 mg et est administré par voie orale. Modafinil a été développé à l'origine dans les années 1970 par le neuroscientifique français Michel Jouvet et les laboratoires Lafon à Ciboure. modiodal sans ordonnance Une fois le cycle commencé, le modafinil n'a plus l'effet escompté. Son poids moléculaire est de 281,32 et sa structure est un analogue morpholine de l'acide 2-thiophèneacétique. Le modafinil a une demi-vie de 7 à 12 heures. Modafinil a été développé à l'origine comme traitement de la narcolepsie. Pour les personnes souffrant de troubles du sommeil, la posologie recommandée est de 200 milligrammes une à trois fois par jour. Comme d'autres stimulants du SNC, le modafinil augmente l'éveil et a montré des preuves limitées d'avantages à court terme dans l'amélioration de l'humeur. Les effets secondaires courants comprennent les maux de tête, les nausées et les vomissements et les étourdissements. Provigil/modafinil est le plus efficace pour réduire les épisodes de somnolence diurne excessive. Le modafinil diffère de la caféine par sa voie d'administration préférée, le modafinil étant mieux absorbé lorsqu'il est pris par voie orale et la caféine étant mieux absorbée lorsqu'elle est prise par voie intraveineuse. Les effets secondaires du modafinil comprennent des maux de tête, des troubles du sommeil et des nausées. Il est lié à 99 % aux protéines plasmatiques et est excrété par les reins (87 %) et le foie (13 %). Bien que le mécanisme d'action exact ne soit pas connu, le modafinil est un analogue de la catécholamine qui agit comme un agoniste de la dopamine. Il n'est pas recommandé chez les personnes souffrant d'arythmie, d'hypertension artérielle importante ou d'hypertrophie ventriculaire gauche.

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#8
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